{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T21:41:42Z","timestamp":1768081302711,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hashimoto's thyroiditis' (HT) impact on the aggressive lymph node (ALN) status of papillary thyroid carcinoma (PTC) remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Univariate and multivariate analyses assessed PTC aggressiveness markers, comparing PTC\u2009+\u2009HT to PTC alone from a single center retrospectively. ALN categorization included &gt;\u20095 positive, \u2265\u20091\u2009&gt;\u20093\u2009cm, and\/or \u2265\u20094 with extranodal extension lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 533 patients with PTC, 19.1% concurrently had HT. Compared to PTC alone, PTC\u2009+\u2009HT patients were predominantly female (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), younger (<jats:italic>p<\/jats:italic>\u2009=\u20090.034), non\u2010smokers (<jats:italic>p<\/jats:italic>\u2009=\u20090.035), and had more pN0 stage tumors (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). PTC\u2009+\u2009HT was associated with lower odds of pN1 stage (OR<jats:sub>adj<\/jats:sub>, 0.50) and lymphatic invasion (OR<jats:sub>adj<\/jats:sub>, 0.53). No significant differences were observed in ALN status, pT stage, lymphatic and perineural invasion, gross ETE, margin, and focality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ALN status does not differ between PTC with or without HT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28031","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T04:25:27Z","timestamp":1734409527000},"page":"1214-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the Association Between Hashimoto's Thyroiditis and Papillary Thyroid Cancer"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0697-2124","authenticated-orcid":false,"given":"Adriana I.","family":"B\u00e1ez Berr\u00edos","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New 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