{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:21:45Z","timestamp":1791814905157,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA226200"],"award-info":[{"award-number":["R21CA226200"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03DE033550"],"award-info":[{"award-number":["R03DE033550"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016672"],"award-info":[{"award-number":["P30CA016672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA261856"],"award-info":[{"award-number":["T32CA261856"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K01DE030524"],"award-info":[{"award-number":["K01DE030524"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R21DE031082"],"award-info":[{"award-number":["R21DE031082"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K12CA088084"],"award-info":[{"award-number":["K12CA088084"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Quantifying head and neck lymphedema and fibrosis (HN\u2010LEF) is crucial in the investigation and management of treatment sequelae in head and neck cancer (HNC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The T1\u2010 and T2\u2010weighted MRI signal intensity (SI) was examined in relation to HN\u2010LEF categories per physical\/tactile examination (No\u2010LEF, A\u2010B\u2009=\u2009edema, C\u2009=\u2009edema + fibrosis, D\u2009=\u2009fibrosis), and MRI structural volumes were examined in relation to a novel 10\u2010point HN\u2010LEF score in the intraoral and submental regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified differences in ranks among HN\u2010LEF categories in relation to the MRI SI (A\u2010B and C are higher than D and No\u2010LEF for T2 SI, and A\u2010B is the highest for T1). Furthermore, six pairs of FOM volumes on MRI demonstrated a strong negative correlation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) with the HN\u2010LEF score at adjacent palpable sites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both MRI SI and structural volumes can potentially be imaging biomarkers of edematous soft tissue states in HNC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28062","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:15:01Z","timestamp":1736554501000},"page":"1487-1496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring Quantitative\n                    <scp>MRI<\/scp>\n                    Biomarkers of Head and Neck Post\u2010Radiation Lymphedema and Fibrosis: Post Hoc Analysis of a Prospective Trial"],"prefix":"10.1002","volume":"47","author":[{"name":"MD Anderson Head and Neck Cancer Symptom Working Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-7497","authenticated-orcid":false,"given":"Shitong","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"McMillan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-7613","authenticated-orcid":false,"given":"Abdallah Sherif Radwan","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Radiation Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Buoy","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel L.","family":"Mulder","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Naser","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem A.","family":"Wahid","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Division of Diagnostic Imaging University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-6807","authenticated-orcid":false,"given":"Amy C.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Division of Radiation Oncology University of Texas MD Anderson Cancer Center  Houston Texas 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