{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:21:15Z","timestamp":1791508875401,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Locoregional external beam radiotherapy (EBRT) is selectively used in thyroid cancer patients to induce locoregional control. However, despite technological advances, EBRT remains associated with toxicities. We evaluated thyroid\u2010cancer specific toxicities and long\u2010term Quality of Life (QoL) post\u2010EBRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      EBRT\u2010treated thyroid cancer patients at Universal Medical Centre Groningen (2007\u20132023) were retrospectively evaluated (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966). Acute (&lt;\u20096\u2009weeks) and late (\u2265\u20093\u2009months) toxicities and QLQ\u2010H&amp;N35 results, prospectively collected as standard patient care, were analyzed (available in 24\/66). Additionally, 17\/66 living patients cross\u2010sectionally completed the QLQ\u2010H&amp;N43 [renewed QLQ\u2010H&amp;N35] and SF\u201036\u2010RAND\u201036.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 24\/66 patients who completed questionnaires during EBRT treatment, most severe acute toxicities occurred around week 6 (91% dermatitis, 74% pain, 70% hoarseness, 65% dysphagia). Late toxicities included persisting acute toxicities and fibrosis. Six months post\u2010treatment, only QLQ\u2010H&amp;N35 domains \u201csocial eating\u201d (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) and \u201cdry mouth\/sticky saliva\u201d (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025) were affected, in comparison to pre\u2010radiation. In the 10\/17 patients who completed the QLQ\u2010H&amp;N35 6\u2009months post\u2010radiation and the cross\u2010sectionally performed QLQ\u2010H&amp;N43, no long\u2010term mitigation of assessed domains was identified in a longitudinal analysis. The most advanced EBRT technique was associated with better QLQ\u2010H&amp;N43 scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EBRT causes acute and late toxicities in most thyroid cancer patients and may be associated with a decreased QoL. As these patients generally survive for multiple years, there is a compelling need to minimize toxicities with more refined radiation techniques, such as proton therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28076","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:52:14Z","timestamp":1737521534000},"page":"1653-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Toxicity and Quality of Life After Locoregional Radiotherapy in Patients With Thyroid Cancer"],"prefix":"10.1002","volume":"47","author":[{"given":"Job W.","family":"van den End","sequence":"first","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline C.","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Surgical Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans H. G.","family":"Verbeek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Oldehinkel","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne H.","family":"Brouwers","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter T.","family":"Zandee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schelto","family":"Kruijff","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Nuclear Medicine and Molecular Imaging University of Groningen, University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5327-1718","authenticated-orcid":false,"given":"Thera 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