{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:53:42Z","timestamp":1754153622227,"version":"3.41.2"},"reference-count":59,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Importance<\/jats:title><jats:p>Laryngeal cancer has undergone a complex evolution in incidence, management, and standards of care over the past 20\u2009years. Disease\u2010wide demographic and survival risk factors have yet to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Examine incidence, management, and survival trends in laryngeal cancer from 2000 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Setting, and Participants<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results database was utilized to identify age\u2010adjusted incidence rates (AAIRs) of laryngeal squamous cell carcinoma (LSCCa) from 2000 to 2019. Joinpoint regression was conducted to identify annual percentage changes (APCs). Chi\u2010squared analysis was used to find changes in demographic, clinicopathologic, and treatment changes over the study period. Finally, univariate Kaplan\u2013Meier and COX multivariate regressions were conducted to identify survival differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 46\u2009266 cases of LSCCa identified between 2000 and 2019 with AAIR of 2.7 per 100\u2009000 person\u2010years with APC of \u22122.6% [95% CI: \u22122.8% to 2.4%]. These rates have largely been down\u2010trending among demographic substratifications. Age at initial diagnosis has been increasing (64.6\u2009\u2192\u200966.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Higher median household income was associated with lower AAIR (35\u2009000 5.3; &gt;\u2009$75\u2009000 2.2) and increased annual percentage decrease (&lt;\u2009$35\u2009000, \u22121.1%*; &gt;\u2009$75\u2009000, \u22123.2%*). There were no other clinically significant differences in demographic and clinicopathologic trends although persistent demographic differences were noted. Late T\u2010stage at diagnosis has increased over the study period (T3, 18%\u2009\u2192\u200923%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Treatment with primary chemoradiotherapy has increased significantly (20.0%\u2009\u2192\u200927.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). On univariate analysis, there were no significant differences in survival; however, on multivariate analysis, there has been a progressive improvement in disease\u2010specific and overall survival over 5\u2010year bins. Late\u2010stage disease had a progressive improvement in survival with each treatment period on both univariate and multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Relevance<\/jats:title><jats:p>There has been a progressively significant decrease in age\u2010adjusted incidence of LSCCa with increased utilization of primary chemoradiotherapy. When adjusted for associated characteristics, there has been a continuing improvement in survival over the study period, primarily in late\u2010stage disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28077","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T01:58:51Z","timestamp":1738375131000},"page":"1816-1830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laryngeal Squamous Cell Carcinoma Incidence and Survival Trends in the United States: A Population\u2010Based Analysis of Two Decades"],"prefix":"10.1002","volume":"47","author":[{"given":"Neel R.","family":"Sangal","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pennsylvania Health System  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-1303","authenticated-orcid":false,"given":"Katherine","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pennsylvania Health System  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine and the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6428-2064","authenticated-orcid":false,"given":"Praneet","family":"Kaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pennsylvania Health System  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Cannady","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pennsylvania Health System  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6639-8830","authenticated-orcid":false,"given":"Robert M.","family":"Brody","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Pennsylvania Health System  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMENT.S8610"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7111a1"},{"key":"e_1_2_10_5_1","unstructured":"National Cancer Institute \u201cSEER Cancer Stat Facts: Laryngeal Cancer \u201dhttps:\/\/seer.cancer.gov\/statfacts\/html\/laryn.html."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1671"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2978"},{"key":"e_1_2_10_8_1","unstructured":"Data From: Surveillance Epidemiology and End Results (SEER) Program \u201cSEER*Stat Database: Incidence\u2014SEER Research Data 8 Registries Nov 2021 Sub (1975\u20132020)\u2014Linked to County Attributes\u2014Time Dependent (1990\u20132020) Income\/Rurality 1969\u20132020 Counties. 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