{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:19:00Z","timestamp":1776701940951,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. The mutational landscape of SNSCCs remains poorly investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV\u2010DNA detection, and E6\/E7 mRNA expression using immunohistochemistry, polymerase chain reaction, and in\u00a0situ hybridization, respectively. In addition, we evaluated the genetic mutations in 59 patients using next\u2010generation sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One\u2010third of the SNSCCs were truly oncogenic HPV\u2010driven tumors associated with a nonkeratinizing morphology (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and did not correlate with the prognosis. The following gene mutations were detected:\n                      <jats:italic>TP53<\/jats:italic>\n                      ,\n                      <jats:italic>PIK3CA<\/jats:italic>\n                      ,\n                      <jats:italic>CDKN2A<\/jats:italic>\n                      ,\n                      <jats:italic>EGFR<\/jats:italic>\n                      , and\n                      <jats:italic>FGFR3<\/jats:italic>\n                      . These mutations occurred alone, in association with, or with oncogenic HPV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>One\u2010third of SNSCCs were high\u2010risk HPV driven lesions. However, gene mutations and HR\u2010HPV infections are not mutually exclusive. Further studies are required to analyze the prognostic value of these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28084","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T04:48:52Z","timestamp":1737780532000},"page":"1726-1735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oncogenic Human Papillomaviruses Drive One\u2010Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations"],"prefix":"10.1002","volume":"47","author":[{"given":"Maxime","family":"Henrion","sequence":"first","affiliation":[{"name":"Departement de Pathologie Centre Hospitalo\u2010Universitaire Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Costes\u2010Martineau","sequence":"additional","affiliation":[{"name":"Departement de Pathologie Centre Hospitalo\u2010Universitaire Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio Gonz\u00e1lez","family":"Bravo","sequence":"additional","affiliation":[{"name":"Laboratoire MIVEGEC, Centre National de la recherche Scientifique (CNRS)  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Boulle","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie des Tumeurs Solides, Centre Hospitalo\u2010Universitaire Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Solassol","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie des Tumeurs Solides, Centre Hospitalo\u2010Universitaire Montpellier  Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Vendrell","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie des Tumeurs Solides, Centre 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