{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:48:21Z","timestamp":1791528501803,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subtotal and total glossectomies for advanced tongue cancer result in significant speech\u2010 and swallow\u2010related morbidity, impairing quality of life. This prospective pilot study compares the safety and functional outcomes associated with using a chimeric innervated muscle and fasciocutaneous flap for soft tissue reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective, non\u2010randomized controlled pilot study evaluated a standardized technique for tongue reconstruction using a chimeric innervated vastus lateralis muscle and anterolateral thigh fasciocutaneous flap. Inclusion criteria were \u2265\u200950% resection of the oral tongue. Participants were followed longitudinally, with measures recorded at baseline, 6\u20138\u2009weeks, 6\u2009months, and 12\u2009months after surgery. The primary endpoints were post\u2010operative complications, time to radiotherapy, operative time, and locoregional failure, videofluoroscopy swallow studies (dynamic imaging grade of swallowing toxicity (DIGEST), penetration and aspiration score, performance status scale for head and neck). Secondary endpoints were patient\u2010rated outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen participants were recruited (10 intervention: 8 controls). Fourteen (78%) experienced complications, only one of which was related to the innervated flap. DIGEST scores deteriorated post\u2010operatively across all participants but did not differ significantly between the intervention and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4) at any point post\u2010surgery, despite more extensive resections in the intervention group. Those in the intervention group had better patient\u2010rated intelligibility (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Multimodality treatment was associated with worse speech (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and normalcy of diet (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Less extensive resections were associated with better scores in eating in public (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), tongue range of movement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0008), intelligibility (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and diet (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The innervated vastus lateralis and antero\u2010lateral thigh free\u2010flap technique is safe and improves speech intelligibility for patients with subtotal and total glossectomy defects. However, the technique requires refinement to optimize functional and quality\u2010of\u2010life outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28087","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T04:19:41Z","timestamp":1738124381000},"page":"1758-1768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Pilot Trial of Tongue Reconstruction Using the Chimeric Innervated Vastus Lateralis Muscle and Antero\u2010Lateral Thigh Free Flap"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-210X","authenticated-orcid":false,"given":"Emma","family":"Charters","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney Australia"},{"name":"School of Health Sciences, Faculty of Medicine and Health The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Boehm","sequence":"additional","affiliation":[{"name":"Speech Pathology Wollongong Hospital  Wollongong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Macdonald","family":"D'Silva","sequence":"additional","affiliation":[{"name":"Speech Pathology Wollongong Hospital  Wollongong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chris O'Brien Lifehouse  Sydney Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon A.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney Australia"},{"name":"Department of Oto\u2010Rhino\u2010Laryngology, Head and Neck Surgery University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsu\u2010Hui (Hubert)","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney Australia"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, Faculty of Medicine and Health Sciences Macquarie University  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney Australia"},{"name":"Royal Prince Alfred Institute of Academic Surgery Sydney Local Health District  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wykes","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney Australia"},{"name":"Royal Prince Alfred Institute of Academic Surgery Sydney Local Health District  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24369"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13191-010-0029-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6548014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/aac.17.3.161.166"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.106301"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.31228"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.6.625"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-2336"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104875"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e3182a6add7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25631"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593772"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.163676"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2013.04.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24668"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24795"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2018.07.009"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-014-9534-9"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30283"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.4703.242"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.4703.256"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1044\/jslhr.4004.708"},{"issue":"7","key":"e_1_2_8_26_1","first-page":"870","article-title":"The Development and Validation of a Dysphagia\u2010Specific Quality\u2010of\u2010Life Questionnaire for Patients with Head and Neck Cancer: the MD Anderson Dysphagia Inventory","volume":"127","author":"Chen A. 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