{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:31:11Z","timestamp":1775007071953,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Airway obstruction secondary to chyle leak is an exceptionally rare phenomenon. Here, we describe this complication in a patient with anaplastic thyroid carcinoma (ATC) undergoing consolidative surgery after BRAF\u2010targeted therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 55\u2010year\u2010old man presented with a rapidly enlarging neck mass. Work\u2010up was consistent with metastatic unresectable BRAF\n                      <jats:sup>V600E<\/jats:sup>\n                      \u2010mutant ATC. After a remarkable response to neoadjuvant dabrafenib and trametinib, he underwent curative\u2010intent surgery with a right hemithyroidectomy and bilateral neck dissection. Within 48\u2009h, he developed an expanding left neck mass with laryngeal obstruction due to a chyle leak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite surgical repair and maximal medical therapy, the leak persisted necessitating thoracoscopic ligation of the thoracic duct. Final pathology showed a completely excised residual tumor. The patient remains disease\u2010free on long\u2010term dabrafenib and trametinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BRAF\u2010directed therapy has transformed the care of patients with mutated ATC. As more patients undergo consolidative surgery, increased vigilance is paramount in minimizing complications and their associated morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28091","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T05:36:05Z","timestamp":1738042565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u201cTension Chyle Leak\u201d: A Life\u2010Threatening Sequela of Thoracic Duct Injury Following Resection of\n                    <scp>BRAF<\/scp>\n                    \u2010Mutated Anaplastic Thyroid Carcinoma"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1193-8831","authenticated-orcid":false,"given":"Karim","family":"Botros","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khashayar","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"Sultanem","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Spicer","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex A.","family":"Mlynarek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Hier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Mascarella","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Jewish General Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.20471\/acc.2022.61.s4.11"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2017.03.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0504"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599821993815"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.2133"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0133"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T13:31:27Z","timestamp":1761139887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,28]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/hed.28091"],"URL":"https:\/\/doi.org\/10.1002\/hed.28091","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,28]]},"assertion":[{"value":"2024-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}