{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:36:28Z","timestamp":1781865388541,"version":"3.54.5"},"reference-count":7,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skull base necrosis can cause life\u2010threatening massive bleeding in patients following radiotherapy and chemotherapy for nasopharyngeal carcinoma. Patients with bilateral internal carotid artery rupture and hemorrhage are especially susceptible, which is a major challenge for clinicians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A team at the Eye and ENT Hospital affiliated with Fudan University recently successfully treated a patient with skull base necrosis after radiotherapy and chemotherapy for nasopharyngeal carcinoma. The patient experienced bilateral internal carotid artery rupture with massive nasopharyngeal hemorrhage and was treated with extracranial\u2013intracranial bypass surgery, resection of the nasal skull base necrotic lesions, and bilateral internal carotid artery occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One week after the last surgery, the patient recovered well, and normal activity was restored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simultaneous EC\u2013IC bypass and TMF repair increase intracranial blood flow compensation without the need for an additional incision, saving the patient's life and improving their quality of life. These results highlight a promising surgical practice for rescuing patients suffering from skull base necrosis and ICA rupture hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28107","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T10:48:48Z","timestamp":1742726928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>EC<\/scp>\u2013<scp>IC<\/scp> Bypass for Skull Base Necrosis and <scp>ICA<\/scp> Rupture Hemorrhage After Radiotherapy for Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9392-264X","authenticated-orcid":false,"given":"Yu","family":"Huang","sequence":"first","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-860X","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xue","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Liu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixing","family":"Zheng","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huankang","family":"Zhang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanpeng","family":"Li","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaole","family":"Song","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Department of Otorhinolaryngology, WeiHai Hospital Qingdao University  Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Department of Otolaryngology, Head and Neck Surgery Chengdu First People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zeng","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery The First Affiliated Hospital of Nanchang University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Nantong University  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine Shandong University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-0942","authenticated-orcid":false,"given":"Xicai","family":"Sun","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor (2018RU003) Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-9103","authenticated-orcid":false,"given":"Hongmeng","family":"Yu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology, Head and Neck Surgery Fudan University Eye Ear Nose and Throat Hospital  Shanghai China"},{"name":"Research Units of New Technologies of Endoscopic Surgery in Skull Base Tumor (2018RU003) Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)30956\u20100"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"61","article-title":"Salvage Endoscopic Surgery for Skull Base Osteoradionecrosis in Nasopharyngeal Carcinoma Patients: A Prospective, Observational, Single\u2010Arm Clinical Study","volume":"61","author":"Dai Q.","year":"2023","journal-title":"Rhinology"},{"issue":"11","key":"e_1_2_6_4_1","first-page":"1294","article-title":"Internal Carotid Artery Embolization in Endoscopic Salvage Surgery for Recurrent Nasopharyngeal Carcinoma: A Single\u2010Center Retrospective Study","volume":"57","author":"Li W. 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