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This study investigates the association between local and systemic oral health determinants and OCSCC in never\u2010smoking adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study using the National Institutes of Health All of Us database was conducted. Lifetime exposures to periodontal disease, acquired absence of teeth, hyperlipidemia, hyperglycemia, HIV, oral\u2010related autoimmune diseases, depression, and eating disorders were analyzed. Multivariate logistic regression estimated odds ratios (ORs) and 95% confidence intervals to identify independent OCSCC risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several risk factors were independently associated with OCSCC: periodontal disease (OR 4.99), hyperlipidemia (OR 1.53), HIV infection (OR 2.96), oral\u2010related autoimmune diseases (OR 2.40), depression (OR 1.51), and eating disorders (OR 8.46). Acquired absence of teeth and hyperglycemia did not show statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study highlights the complex pathophysiology of OCSCC in never\u2010smoking adults and underscores the need for comprehensive risk assessment and prevention strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28119","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:34:00Z","timestamp":1741743240000},"page":"2025-2032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Oral Health Determinants With Oral Squamous Cell Carcinoma in Never\u2010Smoking Adults"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-5873","authenticated-orcid":false,"given":"Peiran","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck 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