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The primary endpoint was the overall response rate (ORR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010one patients were included across 17 Italian sites. Forty\u2010six patients (90%) were evaluated for response: the ORR was 21.7%, with 10 patients achieving a partial response; 24 patients had a stable disease resulting in a disease control rate of 73.9%. At least one treatment\u2010related adverse event (TRAE) was recorded in all patients. The most frequent TRAEs of grade &gt;\u20093 were hypertension (25.5%), stomatitis (17.6%), and fatigue (15.7%); one grade 5 TRAE (bleeding) was reported. Median OS was 16.1\u2009months (95% CI 12.2\u2010NR) with six\u2010month PFS at 75.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lenvatinib confirmed its activity in the real\u2010world population. A higher than expected rate of grade &gt;\u20093 stomatitis was reported.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28124","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:42:50Z","timestamp":1741740170000},"page":"2040-2047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lenvatinib in Relapsed\/Metastatic Adenoid Cystic Carcinoma: Real\u2010World Data From 17 Italian Centers"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1139-5873","authenticated-orcid":false,"given":"Francesca","family":"Caspani","sequence":"first","affiliation":[{"name":"Head and Neck Medical Oncology Department Fondazione IRCCS Istituto Nazionale Dei Tumori  Milan 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