{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:21:22Z","timestamp":1782800482122,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB713"],"award-info":[{"award-number":["2022CFB713"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171972"],"award-info":[{"award-number":["82171972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n To investigate the value of pretreatment nasopharyngeal and neck magnetic resonance imaging (NN\u2010MRI) combined with positron emission tomography (PET)\/CT\u2010guided therapy for improving survival in upper aerodigestive tract NK\/T\u2010cell lymphoma (UADT\u2010NKTL) patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed a prospective cohort study including 171 untreated patients histologically diagnosed with UADT\u2010NKTL, of whom 71 patients received PET\/CT combined with NN\u2010MRI and the other 100 patients received PET\/CT alone. The clinical stage of every patient was classified according to the Ann Arbor and TNM staging systems. Clinical stage, target volume delineation, and survival were evaluated and compared for PET\/CT with and without NN\u2010MRI.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n By detecting additional local lesions,\n NN<\/jats:styled-content>\n \u2010\n MRI<\/jats:styled-content>\n upgraded the clinical stages on the basis of the Ann Arbor staging system and\n TNM<\/jats:styled-content>\n staging system compared to the results of\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n (9\/71,\n p<\/jats:italic>\n \u2009=\u20090.011; 11\/71,\n p<\/jats:italic>\n \u2009=\u20090.019, respectively), which revised the target volume delineation of radiotherapy (9\/71) in the\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n \u2010\n MRI<\/jats:styled-content>\n group. Compared with those in the\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n group, 3\u2010year local recurrence\u2010free survival was prolonged in the\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n \u2010\n MRI<\/jats:styled-content>\n group (100% vs. 74.9%;\n p<\/jats:italic>\n \u2009<\u20090.001), and 3\u2010year overall survival and progression\u2010free survival were better in the\n PET<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n \u2010\n MRI<\/jats:styled-content>\n group (84.5% vs. 76.3%,\n p<\/jats:italic>\n \u2009=\u20090.04 and 78.3% vs. 67.3%,\n p<\/jats:italic>\n \u2009=\u20090.03, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n NN\u2010MRI and PET\/CT\u2010guided therapy could complementarily assist in optimizing the determination of clinical stage and target delineation, which could improve the prognosis of UADT\u2010NKTL patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.28137","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T19:59:32Z","timestamp":1743796772000},"page":"2392-2400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Magnetic Resonance Imaging and [\n 18F<\/scp>\n ]\u2010Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography\u2010Guided Therapy Improves Survival in Upper Aerodigestive Tract\n NK<\/scp>\n \/T\u2010Cell Lymphoma, Nasal Type: A Prospective Cohort Study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-0243","authenticated-orcid":false,"given":"Quanguang","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in Southern China Collaborative Innovation Center of Cancer Medicine Guangzhou China"},{"name":"Department of Oncology 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