{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:38:27Z","timestamp":1754145507415,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Squamous cell carcinoma of the soft palate (SCCSP) represents a rare subtype of oropharyngeal cancer. This study aims to evaluate the treatment outcomes of SCCSP and to assess the prognostic significance of HPV status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with SCCSP between January 1981 and December 2021 were collected. Survival outcomes were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>\n\n<\/jats:title><jats:p>In univariate analysis, primary surgery resulted in superior progression\u2010free survival (PFS), overall survival (OS), and disease\u2010specific survival (DSS) compared with definitive radiotherapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, multivariate analysis revealed that primary surgery independently correlated with superior PFS (HR\u2009=\u20090.37, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), OS (HR\u2009=\u20090.55, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), and DSS (HR\u2009=\u20090.45, <jats:italic>p<\/jats:italic>\u2009=\u20090.020) in early\u2010stage SCCSPs. Additionally, no significant prognostic differences were observed between HPV\/p16 positive and HPV\/p16 negative SCCSPs (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>\n\n<\/jats:title><jats:p>Surgery yields superior oncological outcomes for early\u2010stage SCCSP patients. HPV status does not demonstrate prognostic significance in SCCSP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28143","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T22:35:11Z","timestamp":1743287711000},"page":"2248-2259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Outcomes of Squamous Cell Carcinoma of the Soft Palate and the Prognostic Significance of <scp>HPV<\/scp>\/p16 Status"],"prefix":"10.1002","volume":"47","author":[{"given":"Meng\u2010hua","family":"Li","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Sun Yat\u2010Sen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou 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