{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:27:22Z","timestamp":1774020442764,"version":"3.50.1"},"reference-count":109,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed at identifying acoustic features of airway protective maneuvers as biomarkers of radiation\u2010associated dysphagia, involving penetration\/aspiration and pharyngeal residue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Temporal and spectral acoustical analyses were carried out on voluntary coughs, voluntary throat clearings, and reflexive coughs. Head and neck cancer patients with and without penetration\/aspiration were compared. The same was done for patients and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A decreased convexity of the amplitude contour and decreased salience of periodicity in the frequency band 0\u2013400\u2009Hz were observed in induced reflexive coughs of patients compared to healthy controls. A longer length and a less steep slope of the amplitude contour of voluntary throat clearings were observed in patients with penetration\/aspiration versus those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acoustic features of induced reflexive cough discriminate between patients and healthy controls, but do not relate to penetration\/aspiration. However, acoustic features of voluntary throat clearing are associated with penetration\/aspiration in head and neck cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28163","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T02:15:10Z","timestamp":1744856110000},"page":"2464-2485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acoustic Features of Airway Protective Maneuvers as Biomarkers of Radiation\u2010Associated Dysphagia and Penetration\/Aspiration in Head and Neck Cancer Patients"],"prefix":"10.1002","volume":"47","author":[{"given":"Sofiana","family":"Mootassim\u2010Billah","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Speech Therapy Unit, Institut Jules Bordet, H\u00f4pital Universitaire de Bruxelles (HUB) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Schoentgen","sequence":"additional","affiliation":[{"name":"Department of Biomechatronics Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"De Bodt","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, University Rehabilitation Center for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium; Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Department of Logopaedics and Audiological Sciences, Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hichem","family":"Slama","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Speech Therapy, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (HUB), Universit\u00e9 Libre de Bruxelles, Brussels, Belgium; UR2NF, Neuropsychology and Functional Neuroimaging Research Unit at CRCN Centre de Recherches en Cognition et Neurosciences  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Willemse","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Jules Bordet Institute, H\u00f4pital Universitaire de Bruxelles (HUB) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Dragan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Head and Neck Unit), Institut Jules Bordet, Hopital Universitaire de Bruxelles (HUB) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Roper","sequence":"additional","affiliation":[{"name":"Department of ENT and Head &amp; Neck Surgery, Hopital Universitaire de Bruxelles (HUB) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Le Tensorer","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology and Speech Therapy, Institut Jules Bordet, H\u00f4pital Universitaire de Bruxelles (HUB) Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulus","family":"Kristanto","sequence":"additional","affiliation":[{"name":"Data Center, Unit\u00e9 de Gestion de L'information (UGI), Institut Jules Bordet H\u00f4pital Universitaire de Bruxelles (HUB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Paesmans","sequence":"additional","affiliation":[{"name":"Data Center, Unit\u00e9 de Gestion de L'information (UGI), Institut Jules Bordet H\u00f4pital Universitaire de Bruxelles (HUB)  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Van Gestel","sequence":"additional","affiliation":[{"name":"Radiation\u2010Oncologist Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwen","family":"Van Nuffelen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, University Rehabilitation Center for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium; 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