{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:04:35Z","timestamp":1784887475686,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This review aims to compare survival outcomes of surgical versus non\u2010surgical treatment of advanced\u2010stage OPSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CINAHL, Cochrane Library, PubMed, and Scopus were searched. Studies comparing the survival of patients with advanced OPSCC treated surgically (\u00b1adjuvant therapy) or non\u2010surgically were included. Meta\u2010analyses hazard ratio (HR) and proportions (%) were performed for the outcomes of 2\u2010, 3\u2010, and 5\u2010year overall (OS), disease\u2010free (DFS), disease\u2010specific (DSS), and relapse\u2010free (RFS) survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four studies reporting on (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200935\u2009681) patients were included, with a mean age of 58.9. For advanced\u2010stage disease, primary treatment with surgery and chemoradiotherapy (CRT) demonstrated the best 5\u2010year OS, at 67.1% (95% CI 55.6\u201377.6). Survival outcomes favored Surgery\u2009+\u2009CRT over other primary treatment modalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical treatment with adjuvant CRT may be associated with better OS outcomes compared with non\u2010surgical treatment. Further research is needed to determine superior treatment modalities in OPSCC subgroups, such as HPV+ tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28167","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T05:04:41Z","timestamp":1745039081000},"page":"2486-2498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical Versus Non\u2010Surgical Treatment of Advanced Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8111-1885","authenticated-orcid":false,"given":"Megan K.","family":"Scharner","sequence":"first","affiliation":[{"name":"Medical University of South Carolina College of Medicine  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny M.","family":"Owen","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina College of Medicine  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-4571","authenticated-orcid":false,"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1999-2818","authenticated-orcid":false,"given":"Alexandra E.","family":"Kejner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Brennan","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Libraries  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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