{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:36:45Z","timestamp":1772995005234,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No standard systemic therapy exists for recurrent\/metastatic salivary gland cancer (R\/M SGC). We explored the safety and activity of nivolumab and ipilimumab with palliative hypofractionated radiation (XRT) in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This Phase I\/II Trial enrolled R\/M SGCs with evidence of progression, ECOG 0\u20131, no prior anti\u2010PD\u20101 or CTLA4 therapy, measurable disease excluding the XRT site. Nivolumab 3\u2009mg\/kg iv Q2\u2009weeks\u2009\u00d7\u200912 doses followed by 480\u2009mg iv Q4\u2009weeks\u2009\u00d7\u20098 doses and ipilimumab 1\u2009mg\/kg iv Q6\u2009weeks\u2009\u00d7\u20094 doses was given. Twenty four gray XRT was given over three fractions, 2\u2009weeks after the first dose of nivolumab. The primary endpoint was safety; secondary endpoints included RECIST 1.1 response (non\u2010radiated lesions), progression free, and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between April 2019 and May 2022, 20 pts. were enrolled, the median age was 58 (range 27\u201377\u2009years), 10 (50%) were male, and 12 (60%) had ECOG 0. Five (20%) Grade 3 AEs were observed in three pts.; no Grade 4 or 5 toxicities were observed. Among 19 response\u2010evaluable patients, RECIST 1.1 PRs were observed in 4 (21%), in 2 pts. with salivary duct, 1 acinic cell, and 1 adenoid cystic, SD in 6 (31.5%) and PD in 9 (47.5%). With a median follow\u2010up of 16\u2009months, median OS was 25\u2009months (95% CI: [18.7, 31]) and median PFS was 7.3\u2009months (95% CI [2.5, 18.7]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nivolumab\/ipilimumab and palliative XRT result in low rates of severe toxicities and modest response rates for SGC; further work is necessary to explore predictors for response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28169","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T02:09:12Z","timestamp":1745546952000},"page":"2552-2557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\n                    <scp>PD<\/scp>\n                    \u20101 and\n                    <scp>CTLA4<\/scp>\n                    Immune Checkpoint Blockade and Hypofractionated Radiation in Patients With Advanced Salivary Gland Cancers"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-2630","authenticated-orcid":false,"given":"Cristina P.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian \u201cVicky\u201d","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Ng","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Voutsinas","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Fromm","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana","family":"Dumenigo\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato G.","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington USA"},{"name":"Department of Internal Medicine Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith D.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Santana\u2010Davila","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology\/Oncology University of Washington  Seattle Washington 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