{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:57:21Z","timestamp":1785877041296,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>PharyngoCutaneous Fistulae (PCF) represent a significant clinical challenge in otorhinolaryngology practice. The use of biomaterials could improve outcomes or even replace the use of a flap in pharyngolaryngeal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review included all studies evaluating the application of biomaterials for the prevention of PCF after pharyngeal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 19 articles (12 clinical and 7 animal studies) were included. They assessed the use of a biomaterial to cover mucosal sutures (<jats:italic>n<\/jats:italic>\u2009=\u200915) or to replace a mucosal defect and guide secondary healing (<jats:italic>n<\/jats:italic>\u2009=\u20094). Most studies evaluated commercialized biomaterials (<jats:italic>n<\/jats:italic>\u2009=\u200911) rather than experimental devices (<jats:italic>n<\/jats:italic>\u2009=\u20095) or platelet\u2010derived autologous medical devices (<jats:italic>n<\/jats:italic>\u2009=\u20094).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are already strong arguments to support the use of several biomaterials to cover pharyngeal sutures in order to decrease the rate of PCF after TL or TPL. Replacing a pharyngeal mucosal defect by a biomaterial is currently a more elusive goal.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28175","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:14:47Z","timestamp":1745295287000},"page":"2048-2057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of Biomaterials for the Prevention of Pharyngeal Fistulae: A Systematic Review"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-2846","authenticated-orcid":false,"given":"Emilien","family":"Chabrillac","sequence":"first","affiliation":[{"name":"Department of Surgery University Cancer Institute of Toulouse  Toulouse France"},{"name":"CIRIMAT, Universit\u00e9 Toulouse 3 Paul Sabatier, Toulouse INP, CNRS Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Tourrette","sequence":"additional","affiliation":[{"name":"CIRIMAT, Universit\u00e9 Toulouse 3 Paul Sabatier, Toulouse INP, CNRS Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Habib","sequence":"additional","affiliation":[{"name":"CIRIMAT, Universit\u00e9 Toulouse 3 Paul Sabatier, Toulouse INP, CNRS Universit\u00e9 de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilys","family":"Blanchy","sequence":"additional","affiliation":[{"name":"Rescoll  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Des Courtils","sequence":"additional","affiliation":[{"name":"Laboratoires Brothier  Nanterre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"D'Andr\u00e9a","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Head and Neck Departement Nice University Hospital  Nice France"},{"name":"Unit\u00e9 de Recherche Clinique de la C\u00f4te D'azur, REBOOT Universit\u00e9 C\u00f4te D'azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lavalle","sequence":"additional","affiliation":[{"name":"Inserm UMR_S 1121, CNRS EMR 7003, Universit\u00e9 de Strasbourg, Biomaterials and Bioengineering Centre de Recherche en Biom\u00e9decine de Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Dupret\u2010Bories","sequence":"additional","affiliation":[{"name":"Department of Surgery University Cancer Institute of Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; 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