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Clinical decision\u2010making is commonly guided by limited retrospective evidence. To address this limitation, we performed a systematic review to inform evidence\u2010based consensus for the management of common clinical scenarios, including the potential roles of radiation and systemic therapy to promote structural preservation, elective neck management, and radiation technique considerations. A librarian\u2010mediated literature search identified 39 studies of adult patients with PNS\/NC tumors treated with curative intent that met the study inclusion criteria. Search results were reported using the preferred reporting items for systematic reviews and meta\u2010analyses (PRISMA) methodology. A modified\u2010Delphi process was used to guide consensus for the appropriate use of various management strategies. Strong consensus existed for the appropriateness of primary surgery for early\u2010stage disease, approaches to locally advanced disease with minimal periorbital fat invasion, and the use of induction chemotherapy with response\u2010directed local therapy. Consensus regarding nodal treatment and the use of proton therapy in the adjuvant setting was less robust. The rarity and diversity of PNS\/NC tumors limit randomized phase III trials to guide management. As such, this systematic review and appropriate\u2010use consensus statements provide clinical guidance for the management of this challenging disease spectrum.<\/jats:p>","DOI":"10.1002\/hed.28177","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T03:11:04Z","timestamp":1746760264000},"page":"2073-2091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paranasal Sinus and Nasal Cavity Cancers: Systematic Review and Executive Summary of the American Radium Society Appropriate Use Criteria"],"prefix":"10.1002","volume":"47","author":[{"given":"Matthew E.","family":"Witek","sequence":"first","affiliation":[{"name":"Medstar Georgetown University Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Ward","sequence":"additional","affiliation":[{"name":"Levine Cancer Institute Radiation Oncology, Atrium Health  Charlotte North 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