{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:17:43Z","timestamp":1770153463210,"version":"3.49.0"},"reference-count":81,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006416","name":"Universidade Estadual de Campinas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study investigated the roles of single nucleotide variants (SNVs) in genes of CDDP metabolism and their association with kidney dysfunction in patients with head and neck squamous cell carcinoma (HNSCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 109 patients with locally advanced HNSCC, treated with CDDP, had renal function evaluated by serum creatinine level and CKD\u2010EPI formula, and underwent genotyping by polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:italic>GSTT1<\/jats:italic> present and <jats:italic>ERCC1<\/jats:italic> c.354CT or TT genotypes showed 4.94% and 8.94% renal function reduction, respectively. <jats:italic>GSTT1<\/jats:italic> present with <jats:italic>TP53<\/jats:italic> c.215G&gt;C (17.67%), <jats:italic>GSTP1<\/jats:italic> c.313A&gt;G with <jats:italic>ERCC1<\/jats:italic> c.354C&gt;T (17.57%), <jats:italic>GSTP1<\/jats:italic> c.313A&gt;G with <jats:italic>MLH1<\/jats:italic> c.93G&gt;A (12.49%), <jats:italic>GSTP1<\/jats:italic> c.313A&gt;G with <jats:italic>MSH3<\/jats:italic> c.3133A&gt;G (12.19%), <jats:italic>ERCC1<\/jats:italic> c.354C&gt;T with <jats:italic>MLH1<\/jats:italic> c.93G&gt;A (18.85%) and <jats:italic>ERCC1<\/jats:italic> c.354C&gt;T with <jats:italic>MSH3<\/jats:italic> c.3133A&gt;G (13.38%) combined genotypes were also associated with substantial declines in renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that isolated and combined SNVs in genes enrolled in CDDP metabolism can be used to select patients for treatments that spare the kidneys from adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28179","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:54:30Z","timestamp":1748336070000},"page":"2683-2692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Variability in Cisplatin Metabolism in Kidney Injury in Patients With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiotherapy"],"prefix":"10.1002","volume":"47","author":[{"given":"Ericka Francislaine Dias","family":"Costa","sequence":"first","affiliation":[{"name":"Laboratory of Cancer Genetics, School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria Castro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genetics, School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilda","family":"Mazzali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Jacob","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genetics, School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-2345","authenticated-orcid":false,"given":"Carmen Silvia Passos","family":"Lima","sequence":"additional","affiliation":[{"name":"Laboratory of Cancer Genetics, School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"},{"name":"Department of Radiology and Oncology, School of Medical Sciences University of Campinas  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci11020042"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.4510"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/645460"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000028396"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206933"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/35094000"},{"key":"e_1_2_11_8_1","first-page":"47","article-title":"Cisplatin Nephrotoxicity: Molecular Mechanisms","volume":"1","author":"Hanigan M. H.","year":"2003","journal-title":"Cancer Therapy"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133243"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2018.11.019"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12842"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428320938494"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15061759"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0518-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7668"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25268"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45808-6"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2009.45"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.93"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.140"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/937429"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.018"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.016"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2102953"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008876115797"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011023431804"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-S011"},{"key":"e_1_2_11_29_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar A. K.","year":"2017"},{"key":"e_1_2_11_30_1","first-page":"21","volume-title":"AJCC Cancer Staging Manual","author":"Edge S. B.","year":"2010"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.8.1245"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.02.007"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.066006383.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1250"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102605.2007.00842.x"},{"issue":"4","key":"e_1_2_11_36_1","first-page":"1354","article-title":"Modulation of Nucleotide Excision Repair Capacity by XPD Polymorphisms in Lung Cancer Patients","volume":"61","author":"Spitz M. R.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgl257"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp065"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20359"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201005\u20100834"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2009.03.011"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2007.12.014"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20397"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1198"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.030106"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.7.645"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29435"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209373"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0635"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/19.2.275"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.08.006"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0086"},{"issue":"3","key":"e_1_2_11_53_1","first-page":"555","article-title":"Comparison of Two Human Ovarian Carcinoma Cell Lines (A2780\/CP70 and MCAS) That Are Equally Resistant to Platinum but Differ at Codon 118 of the ERCC1 Gene","volume":"16","author":"Yu J. J.","year":"2000","journal-title":"International Journal of Oncology"},{"issue":"3","key":"e_1_2_11_54_1","first-page":"809","article-title":"Functional Effects of the MLH1\u201093G>A Polymorphism on MLH1\/EPM2AIP1 Promoter Activity","volume":"25","author":"Perera S.","year":"2011","journal-title":"Oncology Reports"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121136498"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11091083"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1060603"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093"},{"issue":"15","key":"e_1_2_11_59_1","first-page":"4327","article-title":"Functional FAS Promoter Polymorphisms Are Associated With Increased Risk of Acute Myeloid Leukemia","volume":"63","author":"Sibley K.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19229"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.132"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2017.1298001"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7578"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11100949"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-016-2966-1"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010141"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-023-02454-3"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-024-04303-2"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155219901305"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000464"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-020-0398-3"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510384"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008944.pub3"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00631-7"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01831-9"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1068863"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.11.006"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914574"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.21939"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs369"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10050364"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2023.151341"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T09:09:01Z","timestamp":1757927341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/hed.28179"],"URL":"https:\/\/doi.org\/10.1002\/hed.28179","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"assertion":[{"value":"2025-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}