{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:32:07Z","timestamp":1780536727858,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Artificial intelligence (AI)\u2010based imaging analysis and circulating tumor\u2010associated DNA (ctDNA) are both being used diagnostically in HPV\u2010driven oropharynx squamous cell carcinoma (HPV\u2010OPSCC). We evaluated associations between AI\u2010measured tumor burden and ctDNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 170 patients treated definitively for HPV\u2010OPSCC. All had pre\u2010treatment serum tumor\u2010tissue modified viral (TTMV) ctDNA levels. An AI algorithm measured tumor and lymph nodes on CT scans. Linear regressions detected associations between ctDNA (fragments\/mL) and automated volumes, clinical tumor (T) and nodal (N) stage, and disease factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Automated tumor volume (coeff\u2009=\u200939.43, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), nodal volume (coeff\u2009=\u200939.54, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), T stage (coeff\u2009=\u20091031.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), and N stage (coeff\u2009=\u20091840, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) were associated with ctDNA. On multivariable analysis, tumor (coeff\u2009=\u200934.79, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and nodal volumes (coeff\u2009=\u200924.68, <jats:italic>p<\/jats:italic>\u2009=\u20090.022) were associated with ctDNA; T and N stage were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Automated volumetrics are independently and more strongly associated with ctDNA, compared with clinical stage. Automated volumetrics provide a practical correlate to ctDNA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28180","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T05:51:16Z","timestamp":1746424276000},"page":"2641-2649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Artificial Intelligence Measured Tumor Burden and Pre\u2010Treatment Circulating Tumor <scp>DNA<\/scp> in Human Papilloma Virus\u2010Associated Oropharynx Cancer"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-3913","authenticated-orcid":false,"given":"Mina","family":"Bakhtiar","sequence":"first","affiliation":[{"name":"Harvard Radiation Oncology Program Brigham &amp; Women's Hospital and Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Artificial Intelligence in Medicine (AIM) Program Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhong","family":"Ye","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Medicine (AIM) Program Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Radiation Oncology Brigham &amp; Women's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Schoenfeld","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Brigham &amp; Women's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homan","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Mayo Clinic Jacksonville  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P.","family":"Guenette","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology Brigham &amp; Women's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni M.","family":"Rettig","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Brigham &amp; Women's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Medical Oncology Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin H.","family":"Kann","sequence":"additional","affiliation":[{"name":"Artificial Intelligence in Medicine (AIM) Program Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Radiation Oncology Brigham &amp; Women's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Centers for Disease Control \u201cCancers Linked HPV Each Year \u201dhttps:\/\/www.cdc.gov\/cancer\/hpv\/cases.html."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2023.1937"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6064"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.0159"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03137-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3282"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02444"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy251"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.08.014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.44783"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7594"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.01.112"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00045"},{"issue":"11","key":"e_1_2_11_15_1","first-page":"120","article-title":"The OpenCV Library","volume":"25","author":"Bradski G.","year":"2000","journal-title":"Dr. Dobb's Journal: Software Tools for the Professional Programmer"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01008-z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-27420-6_6"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3348\/jksr.2015.72.4.271"},{"key":"e_1_2_11_19_1","unstructured":"StataCorp \u201cStata: Release 17. 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