{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:49:26Z","timestamp":1758055766957,"version":"3.44.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chemoradiotherapy for head and neck cancer often causes trismus and xerostomia\u2010induced dental caries, impairing quality of life. Current interventions have compliance and efficacy issues. This study developed a patient\u2010customized oral appliance to address both conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A fluoride delivery appliance was designed using an interactive approach and decision\u2010matrix scoring. A longitudinal clinical study (<jats:italic>n<\/jats:italic>\u2009=\u200930) evaluated its impact on mouth opening, salivary flow, and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final design featured a posterior occlusal support, enhancing mandibular mobility and fluoride delivery. At 5\u2009years postradiotherapy, benefits included improved saliva flow, reduced dental caries, pain\u2010free full mouth opening, and enhanced eating and speaking functions. The Gothenburg Trismus Questionnaire scores indicated superior recovery over standard fluoride trays (<jats:italic>p<\/jats:italic>\u2009=\u20090.0002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel oral appliance offers a dual\u2010function, patient\u2010customized approach to improving mandibular mobility and salivary function, ultimately enhancing long\u2010term quality of life for head and neck cancer survivors after chemoradiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28183","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T02:29:10Z","timestamp":1746671350000},"page":"2672-2682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Patient\u2010Customized Oral Appliance to Prevent Trismus and Improve Salivary Function in Head and Neck Cancer Survivors"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5244-1534","authenticated-orcid":false,"given":"Allan","family":"Chung","sequence":"first","affiliation":[{"name":"Doctoral Program in Design College of Design, National Taipei University of Technology  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Ting","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering Yuan Ze University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu\u2010Yuan","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Dentistry Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ruei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dentistry Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te\u2010Chin","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Dentistry Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5307-9715","authenticated-orcid":false,"given":"Yo\u2010Wen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Industrial Design National Taipei University of Technology  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-4442","authenticated-orcid":false,"given":"Yih\u2010Lin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Koo Foundation Sun Yat\u2010Sen Cancer Center  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.07.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.6647"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.06.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2023.02.007"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-023-07605-w"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-021-10398-x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.03.005"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24366"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.05.001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3131-4"},{"issue":"4","key":"e_1_2_12_12_1","first-page":"E1","article-title":"Impact of Exercise With TheraBite Device on Trismus and Health\u2010Related Quality of Life: A Prospective Study","volume":"96","author":"Montalvo C.","year":"2017","journal-title":"Ear, Nose, and Throat Journal"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"66","article-title":"The Evaluation of TheraBite and Wooden Tongue Depressor in the Treatment of Trismus and Health\u2010Related Quality of Life","volume":"27","author":"\u015eahan M. 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