{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:48:42Z","timestamp":1758055722896,"version":"3.44.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenoid cystic carcinoma (ACC) is the second most common and treatment\u2010resistant salivary gland carcinoma (SGC). Although platinum\u2010based therapies are effective, the efficacy of eribulin, a microtubule inhibitor with an 18% response rate in a Phase II trial involving recurrent\/metastatic SGC, in patients with advanced ACC after platinum therapy remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 19 patients with unresectable\/metastatic ACC treated with platinum\u2010based therapy between December 2015 and January 2023 at the National Cancer Center Hospital, Japan. Ten patients received eribulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 61\u2009years. 84% achieved disease control with the first\u2010line or later platinum\u2010based therapy (median progression\u2010free survival [mPFS]: 7.6\u2009months). Second\u2010line or later eribulin monotherapy yielded a 50% disease control rate, with mPFS of 3.7\u2009months and median overall survival of 41.7\u2009months. The adverse events, predominantly neutropenia, were manageable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eribulin shows promising effects of unresectable\/metastatic ACC, offering tolerable adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28190","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:04:03Z","timestamp":1747721043000},"page":"2735-2741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Eribulin Monotherapy in Patients With Unresectable and\/or Metastatic Adenoid Cystic Carcinoma Receiving Platinum\u2010Based Therapy"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-7741","authenticated-orcid":false,"given":"Tomomi","family":"Sanomachi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3603-8575","authenticated-orcid":false,"given":"Tatsunori","family":"Shimoi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Esophageal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoko","family":"Arakaki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitomi Sumiyoshi","family":"Okuma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munehiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shosuke","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadaaki","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-7883","authenticated-orcid":false,"given":"Taisuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Yonemori","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"56","article-title":"Adenoid Cystic Carcinoma of Salivary Gland: A Ten\u2010Year Single Institute Experience","volume":"46","author":"Belulescu I. 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