{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:26:50Z","timestamp":1785594410333,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K12794"],"award-info":[{"award-number":["25K12794"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K09731"],"award-info":[{"award-number":["22K09731"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>NTRK<\/jats:italic>\n                      fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable. Here, we report a case of salivary gland secretory carcinoma in which conversion surgery was performed after TRK inhibitor use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The patient was a 33\u2010year\u2010old man with a left parotid gland tumor. Examinations revealed a tumor invading the poststyloid compartment and\n                      <jats:italic>ETV6<\/jats:italic>\n                      \u2010\n                      <jats:italic>NTRK3<\/jats:italic>\n                      fusion gene expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Entrectinib administration shrunk the tumor to a size surgically resectable with an adequate margin. The patient underwent total parotidectomy with left supraomohyoid neck dissection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Conversion surgery and TRK inhibitor use were effective against unresectable parotid gland carcinoma with the\n                      <jats:italic>NTRK<\/jats:italic>\n                      fusion gene. The case provides a reference for conversion surgery use for unresectable parotid gland carcinomas.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28196","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:49:37Z","timestamp":1747633777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Conversion Surgery After Administration of a\n                    <scp>TRK<\/scp>\n                    Inhibitor for Unresectable Parotid Gland Secretory Carcinoma"],"prefix":"10.1002","volume":"47","author":[{"given":"Arisa","family":"Nagano","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2043-678X","authenticated-orcid":false,"given":"Takuma","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Minohara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-6941","authenticated-orcid":false,"given":"Sho","family":"Iwaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsuge","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sekai","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satsuki","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Murase","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery International University of Health and Welfare Mita Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya 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Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:25:46Z","timestamp":1761125146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/hed.28196"],"URL":"https:\/\/doi.org\/10.1002\/hed.28196","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2025-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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