{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:51:55Z","timestamp":1784613115543,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The past two decades have seen a paradigm shift in the surgical treatment of sinonasal malignancies, moving from traditional open approaches to minimally invasive endoscopic techniques. Technological advancements have enabled the use of the endoscopic endonasal transcribriform approach (EETA) for tumors involving the anterior skull base (ASB). This study evaluates the oncologic outcomes of EETA for locally advanced sinonasal malignancies with ASB involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective cohort study at a tertiary cancer center, including patients treated with EETA for sinonasal malignancies from January 2012 to January 2024. Data on demographic characteristics, clinical presentations, treatment protocols, and survival outcomes were analyzed. Survival probabilities were assessed using Kaplan\u2013Meier curves, and subgroups comparisons were made using the log rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine patients were included, predominantly with primary tumors (91.8%) and advanced stages (cT3\u2013T4: 89.8%). EETA achieved R0 resection in 82.1% of cases. All eligible patients (88.9%) underwent postoperative radiotherapy, with 97.5% beginning treatment 6\u20138\u2009weeks after surgery. The mean follow\u2010up duration was 43.2\u2009months. The 5\u2010year overall survival (OS) was 66.5%, disease\u2010free survival (DFS) was 58.7%, and local relapse\u2010free survival (LRFS) was 75%. Patients with olfactory neuroblastoma had significantly higher OS and DFS compared to intestinal\u2010type adenocarcinoma. Margin status significantly impacted survival, with better outcomes observed in patients with clear margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>EETA offers a viable and effective alternative for treating locally advanced sinonasal malignancies with ASB involvement, achieving acceptable oncologic outcomes with reduced morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hed.28197","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T02:58:16Z","timestamp":1748314696000},"page":"2348-2357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Oncologic Outcomes of Endoscopic Endonasal Transcribriform Approach for Locally Advanced Sinonasal Malignancies"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-1102","authenticated-orcid":false,"given":"Michel","family":"Khalaf","sequence":"first","affiliation":[{"name":"Department of Head Neck &amp; Skull Base Surgery Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"De Kermadec","sequence":"additional","affiliation":[{"name":"Department of Head Neck &amp; Skull Base Surgery Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Hershkovitch","sequence":"additional","affiliation":[{"name":"Department of Head Neck &amp; Skull Base Surgery Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Department of Pathology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bidault","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois\u2010R\u00e9gis","family":"Ferrand","sequence":"additional","affiliation":[{"name":"Department of Head &amp; Neck Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Temam","sequence":"additional","affiliation":[{"name":"Department of Head Neck &amp; Skull Base Surgery Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-3409","authenticated-orcid":false,"given":"Pierre","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Gustave Roussy  Villejuif France"},{"name":"Universit\u00e9 Paris\u2010Saclay  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bresson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay  France"},{"name":"Department of Neurosurgery Foch Hospital  Suresnes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-1762","authenticated-orcid":false,"given":"Antoine","family":"Moya Plana","sequence":"additional","affiliation":[{"name":"Department of Head Neck &amp; 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