{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:25:09Z","timestamp":1769635509011,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumor budding (TB) is characterized by isolated tumor cells or cell clusters at the invasive tumor front in squamous cell carcinoma (SCC) of the tongue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This research (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200961) aimed to analyze the diagnostic methodology of TB, the association between the tumoral features and TB, the immunohistochemical characteristics and their correlation with the TB index (TBI), assess the prognostic factors of TB in relation to cervical metastases and analyze disease\u2010free survival (DFS) and overall survival (OS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A statistically significant association was found between TB and depth of invasion (DOI), perineural invasion, E\u2010Cadherin expression, and Ki\u201067 index. Regarding cervical metastases, a statistically significant association was observed with DOI, perineural invasion, TBI, E\u2010Cadherin expression, and Ki\u201067 index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TB correlates significantly with DOI and perineural invasion. Patients with a high TBI are associated with decreased E\u2010cadherin expression and an increased Ki\u201067 index. TBI is an independent prognostic factor for the presence of cervical lymphatic metastases, and no association was found between the TBI and DFS or OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28204","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:09:08Z","timestamp":1750309748000},"page":"325-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Relevance of Tumor Budding at the Invasive Tumor Front in Early\u2010Stage Oral Tongue Squamous Cell Carcinoma: Histological and Immunohistochemical Analysis"],"prefix":"10.1002","volume":"48","author":[{"given":"Samuel Esp\u00edas","family":"Alonso","sequence":"first","affiliation":[{"name":"Maxillofacial Surgery Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Alijo","family":"Serrano","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio Navarro","family":"Cu\u00e9llar","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L\u00f3pez","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Fern\u00e1ndez","family":"Acosta","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja Gonz\u00e1lez","family":"Moure","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Department Hospital Universitario Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Zamorano","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Public Health and Maternal &amp; 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