{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:55:23Z","timestamp":1791809723891,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018724","name":"R\u00e9seau de canc\u00e9rologie Rossy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is associated with increased treatment toxicity and survival in head and neck squamous cell cancer (HNSCC). This study evaluates sarcopenia trajectories and their association with overall survival (OS) and disease\u2010free survival (DFS) in operable HNSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pre\u2010 and post\u2010treatment body composition metrics of patients with stage II\u2010IV HPV\u2010negative HNSCC undergoing surgery were performed. Sarcopenia trajectories were categorized as remains sarcopenic, remains non\u2010sarcopenic, recovers from sarcopenia, or progresses to sarcopenia using multiple Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 332 patients, 108 were sarcopenic at baseline, and 106 remained sarcopenic post\u2010treatment. Patients who remained sarcopenic or progressed to sarcopenia demonstrated significantly worse OS (HR: 2.08, 95% CI: 1.27\u20133.41 and HR: 3.05, 95% CI: 1.40\u20136.62) and DFS (HR: 1.79, 95% CI: 1.17\u20132.72 and HR: 2.12, 95% CI: 1.03\u20134.36), compared to those who remained non\u2010sarcopenic while adjusting for confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sarcopenia trajectories represent dynamic biomarkers that predict oncologic outcome in patients with operable HNSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28210","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T02:39:25Z","timestamp":1749523165000},"page":"2929-2938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sarcopenia Trajectories Predict Survival in Operable Head and Neck Cancer"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-805X","authenticated-orcid":false,"given":"Marco A.","family":"Mascarella","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Department of Otolaryngology McGill University  Montreal Quebec Canada"},{"name":"Centre for Clinical Epidemiology Lady Davis Institute of the Jewish General Hospital  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Mlynarek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kost","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Zeitouni","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Sultanem","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tsien","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Shenouda","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Bouganim","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashayar","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Department of Oncology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-2668","authenticated-orcid":false,"given":"Nader","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology McGill University  Montreal Quebec 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