{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:36:06Z","timestamp":1769045766362,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hypopharyngeal squamous cell carcinoma (HPSCC) and esophageal squamous cell carcinoma (ESCC) share common risk factors such as alcohol consumption and smoking, leading to synchronous or metachronous diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 24 formalin\u2010fixed paraffin\u2010embedded tissue specimens of surgically treated HPSCC and ESCC from 12 Japanese patients. Targeted sequencing of 409 cancer\u2010related genes was conducted and mutational signatures were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most frequent somatic driver mutation identified was in\n                      <jats:italic>TP53<\/jats:italic>\n                      (39.5%). Although driver mutations were detected in the same genes in seven patients, no identical clonal mutations were identified between HPSCC and ESCC. Eight patients had either heterozygous or homozygous polymorphisms of aldehyde dehydrogenase 2 (ALDH2) associated with reduced enzymatic activity. The mutational signature analysis showed SBS5 and SBS18 mutation patterns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The present findings suggest that common somatic mutations of\n                      <jats:italic>TP53<\/jats:italic>\n                      in conjunction with\n                      <jats:italic>ALDH2<\/jats:italic>\n                      polymorphisms contribute to the development of synchronous and metachronous HPSCC and ESCC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28220","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:14:17Z","timestamp":1750313657000},"page":"3028-3038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Somatic Mutations in Primary Squamous Cell Carcinomas of the Hypopharynx and the Esophagus Developed in Individual Patients"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7091-6714","authenticated-orcid":false,"given":"Hidetoshi","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Hyogo Cancer Center  Akashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-4871","authenticated-orcid":false,"given":"Ken\u2010Ichi","family":"Nibu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7545","authenticated-orcid":false,"given":"Hirotaka","family":"Shinomiya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery Kobe University Graduate School of Medicine  Kobe 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