{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:00:16Z","timestamp":1772996416601,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There is limited evidence on the role of adjuvant external beam radiotherapy in differentiated thyroid cancer (DTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective study of patients with DTC treated with adjuvant Intensity Modulated radiotherapy (IMRT) from 2011 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010nine patients were analyzed with median follow\u2010up of 53\u2009months. All the patients had undergone total thyroidectomy. Gross extrathyroidal extension was seen in 76% of patients, while 54% had R1\/R2 resection. High\u2010risk histological types were seen in 51% of patients, while 34% had recurrent disease. The 5\u2010year locoregional control (LRC) was 89.3% while 5\u2010year overall survival (OS) was 84.6%. Acute Grade 3 dermatitis and dysphagia were seen in 12% and 10%, respectively. Late toxicity, including tracheostomy placement and feeding tube dependence, was seen in three and one patient, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjuvant IMRT in patients with DTC with high risk of locoregional recurrence resulted in good LRC with acceptable toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28222","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:21:27Z","timestamp":1752571287000},"page":"3285-3293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant External Beam Radiotherapy in Differentiated Thyroid Cancers: An Audit of Clinical Practice, Adapting to\u00a0New Evidence"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0744-4838","authenticated-orcid":false,"given":"Sarbani Ghosh","family":"Laskar","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samarpita","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwetabh","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gouri","family":"Pantvaidya","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-3338","authenticated-orcid":false,"given":"Shivakumar","family":"Thiagarajan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-7859","authenticated-orcid":false,"given":"Ashwini","family":"Budrukkar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monali","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Vaish","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidisha","family":"Tuljapurkar","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrashekhar","family":"Dravid","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rathan","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8119-8439","authenticated-orcid":false,"given":"Arjun Gurmeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801293380506"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_9_4_1","unstructured":"National Comprehensive Cancer Network \u201cNCCN Clinical Practice Guidelines in Oncology: Thyroid Carcinoma \u201d2024 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/thyroid.pdf."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.4.7407"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.12.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2008.09.023"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.2077"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2017.00192"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2018-0038"},{"issue":"3","key":"e_1_2_9_11_1","first-page":"89","article-title":"Clinical Outcomes of Adjuvant External\u2010Beam Radiotherapy for Differentiated Thyroid Cancer \u2010 Results After 874 Patient\u2010Years of Follow\u2010Up in the MSDS\u2010Trial","volume":"48","author":"Biermann M.","year":"2009","journal-title":"Journal of Nuclear Medicine"},{"issue":"1","key":"e_1_2_9_12_1","first-page":"E2297","article-title":"External Beam Radiotherapy in Differentiated Thyroid Carcinoma: A Systematic Review","volume":"38","author":"Fussey J. M.","year":"2016","journal-title":"Head & Neck"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26133"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300891621996817"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.24357"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2012.09.007"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03300-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12515"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444393"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02358.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.759049"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0650"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25639"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00382-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406470"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4391"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.14338\/IJPT\u2010D\u201020\u201000053"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.28222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:01:04Z","timestamp":1772985664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/hed.28222"],"URL":"https:\/\/doi.org\/10.1002\/hed.28222","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2025-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}