{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:51:28Z","timestamp":1779371488271,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Endoscopic surgery of T1a glottic squamous cell carcinoma (SCC) is believed to have advantages compared to radiotherapy (RT), including short duration, cost\u2010effectiveness, repeatability, and RT reserved for second tumors\/failures. The equality of tumor control probability after treatments is unresolved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the DAHANCA 27 phase II study, selected Danish patients suspected of T1a glottic SCC between 2012 and 2016 were offered one\u2010step diagnostic and curatively intended transoral laser microsurgery (TLM). The 5\u2010year outcome was compared to a 2003\u20132012 national cohort of T1a glottic SCC patients treated with accelerated RT (accRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The TLM (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200994) treatment included cordectomy type I (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944), II (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938), and III (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912). Failure was observed in 10\/94 TLM and 36\/534 accRT patients, resulting in 1 and 23 laryngectomies, respectively. The 5\u2010year laryngectomy\u2010free disease\u2010specific survival was TLM 97.9% and accRT 94.6%, HR: 0.37 (0.09, 1.54).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Primary TLM for selected T1a glottic SCC patients is an organ preserving treatment with high disease control comparable to accRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28225","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:52:10Z","timestamp":1751878330000},"page":"3228-3236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The\n                    <scp>DAHANCA<\/scp>\n                    27 Phase\n                    <scp>II<\/scp>\n                    Study: Transoral Laser Microsurgery for\n                    <scp>T1aN0M0<\/scp>\n                    Glottic Squamous Cell Carcinoma, a Comparison to Accelerated Radiotherapy"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7675-1164","authenticated-orcid":false,"given":"Nina M.","family":"Lyhne","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery and Audiology Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery and Audiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper F.","family":"Tvedskov","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery and Audiology, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Godballe","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark and Clinical Department, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Hald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head and Neck Surgery and Audiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte P.","family":"Ulh\u00f8i","sequence":"additional","affiliation":[{"name":"Department of Pathology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine","family":"Printz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology \u2010 Head &amp; Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark and Clinical Department, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Overgaard","sequence":"additional","affiliation":[{"name":"Department of Experimental Clinical Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.02.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.01.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21686"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2017.1353706"},{"key":"e_1_2_9_6_1","first-page":"1","article-title":"Systematic Review and Meta\u2010Analysis of T1 Glottic Cancer Outcomes Comparing CO 2 Transoral Laser Microsurgery and Radiotherapy","volume":"2","author":"Vaculik M. 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