{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:09:34Z","timestamp":1780524574240,"version":"3.54.1"},"reference-count":79,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluates the risk of persistent opioid use (POU) among thyroidectomy patients given postoperative opioids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing thyroidectomy were identified using the TriNetX Research Platform (2010\u20132024). Cohorts were divided based on opioid prescriptions on the day of surgery. With propensity score matching to prevent confounding bias, risk ratios were calculated for opioid prescriptions 3\u20139\u2009months post\u2010surgery. Secondary outcomes included ED presentation, pain diagnosis, and lifetime risk of opioid use disorder, defined as significant social dysfunction due to uncontrolled use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The post\u2010match opioid group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919,727) experienced a 4.61% risk of POU (control: 4.07%), representing a 14% higher risk of POU compared to the non\u2010opioid group (RR 1.14, 95% CI: [1.03, 1.25]). Opioids slightly decreased the likelihood of outpatient visits at 30\u2009days (RR: 0.97 [0.95, 0.98]) and 90\u2009days (RR: 0.96 [0.94, 0.97]) following surgery. There were no significant differences in ED presentation, pain diagnoses at 30 and 90\u2009days, or lifetime OUD risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post\u2010thyroidectomy opioid prescription modestly increases POU risk, highlighting the need for careful patient counseling and judicious use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28232","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T05:43:19Z","timestamp":1751262199000},"page":"3098-3105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post\u2010Thyroidectomy Opioid Prescription and Risk of Persistent Opioid Use: A Propensity Matched Cohort Study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4824-7160","authenticated-orcid":false,"given":"Oluwatobiloba","family":"Ayo\u2010Ajibola","sequence":"first","affiliation":[{"name":"Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1324-5618","authenticated-orcid":false,"given":"Milan P.","family":"Fehrenbach","sequence":"additional","affiliation":[{"name":"University of Kentucky College of Medicine  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3631-463X","authenticated-orcid":false,"given":"Asher C.","family":"Park","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-7143","authenticated-orcid":false,"given":"Jonathan D.","family":"West","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology\u2010Head and Neck Surgery Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-4830","authenticated-orcid":false,"given":"Daniel I.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Caruso Department of Otolaryngology\u2010Head and Neck Surgery Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"National Institute on Drug Abuse (NIDA) \u201cAbuse NI on D. 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