{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:00:00Z","timestamp":1772996400831,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The optimal intravenous (IV) antibiotic regimen following definitive surgical treatment for mandibular osteoradionecrosis (ORN) is unknown. This study evaluated the effect of culture\u2010directed IV antibiotics (based on intraoperative cultures) on early wound complications, including surgical site infections (SSIs) and antibiotic duration on long\u2010term wound healing (healing \u2264\u20092 months without subsequent complications).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective review of flap reconstruction for ORN (2009\u20132022,\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200944, 70% free flaps, 30% pedicled).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Postoperative antibiotics were culture\u2010directed (25 patients) or empiric (19); the SSI rate was lower in the culture\u2010directed group (0% vs. 26.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). Twenty\u2010two patients received short\u2010course (mean 9\u2009days) and 22 long\u2010course (mean 43\u2009days) IV antibiotics postoperatively. During follow\u2010up (mean 5.7\u2009years), these groups had similar rates of long\u2010term wound healing (50% vs. 36%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.54).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this series, patients who received culture\u2010directed IV antibiotics postoperatively had zero SSIs. The rate of long\u2010term wound healing was not affected by the antibiotic duration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28235","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:42:58Z","timestamp":1751870578000},"page":"3237-3244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Postoperative Antibiotics on Outcomes Following Segmental Resection and Microvascular Reconstruction for Mandibular Osteoradionecrosis"],"prefix":"10.1002","volume":"47","author":[{"given":"Marta M.","family":"Williams","sequence":"first","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Francis X.","family":"Creighton","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medicine  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam B.","family":"Barshak","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-6549","authenticated-orcid":false,"given":"Jeremy D.","family":"Richmon","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derrick T.","family":"Lin","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G.","family":"Deschler","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0915-0382","authenticated-orcid":false,"given":"Kevin S.","family":"Emerick","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-5672","authenticated-orcid":false,"given":"Mark A.","family":"Varvares","sequence":"additional","affiliation":[{"name":"Massachusetts Eye and Ear  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-9544","authenticated-orcid":false,"given":"Marlene L.","family":"Durand","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2023.2257316"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12318"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27310"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30803"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000424"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100040\u20101721759"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010021\u201001680\u20104"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0000000000000459"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28399"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.08.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21715"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.03.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001445"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.12.068"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101326731"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/21.suppl_C.115"},{"key":"e_1_2_7_18_1","unstructured":"CDC \u201cSurgical Site Infection Basics. 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