{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:00:06Z","timestamp":1772996406694,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malignant pediatric jaw tumors are rare but challenging entities. While unresectable tumors are typically managed with chemotherapy and supportive care, our institution advocates for aggressive surgery to reduce local disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed children treated for jaw tumors at a tertiary children's hospital (2006\u20132024). Patients with maxillary or mandibular cancers and distant metastases who underwent palliative resection followed by microsurgical reconstruction were included. Data on demographics, oncologic history, and outcomes were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven patients (mean 13.1\u2009years) underwent resection compared to two unresected patients. Reconstruction utilized free osteocutaneous fibula (4), anterolateral thigh (2), and rectus abdominis (1). Positive resection margins occurred in 57%, with no flap losses but 43% requiring revision. Four patients expired (mean 1.3\u2009years post\u2010surgery). Most patients showed improvement in pain, feeding, and speech.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aggressive surgical management of metastatic pediatric jaw cancers can improve quality of life, despite incomplete resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28241","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:39:54Z","timestamp":1751877594000},"page":"3221-3227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Free Flap Reconstruction for Malignant Pediatric Jaw Tumors: A Palliative Approach"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7220-8102","authenticated-orcid":false,"given":"Raina K.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine  Fort Lauderdale Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Mejia","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Division of Plastic and Reconstructive Surgery Keck School of Medicine  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Bakovic","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8826-3184","authenticated-orcid":false,"given":"Asli","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Division of Plastic and Reconstructive Surgery Keck School of Medicine  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvee","family":"Turk","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Naidu","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Urata","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Division of Plastic and Reconstructive Surgery Keck School of Medicine  Los Angeles California USA"},{"name":"Division of Oral and Maxillofacial Surgery Keck School of Medicine  Los Angeles California USA"},{"name":"Herman Ostrow School of Dentistry, University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Hammoudeh","sequence":"additional","affiliation":[{"name":"Division of Plastic and Maxillofacial Surgery Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Division of Plastic and Reconstructive Surgery Keck School of Medicine  Los Angeles California USA"},{"name":"Division of Oral and Maxillofacial Surgery Keck School of Medicine  Los Angeles California USA"},{"name":"Herman Ostrow School of Dentistry, University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23499-6_846"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.2895"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2014.09.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1006622"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010017\u20101017\u20108"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912\u2010021\u201001170\u20103"},{"issue":"7","key":"e_1_2_7_8_1","first-page":"1266","article-title":"Classification of Mandibular Defects","volume":"92","author":"Boyd J. B.","year":"1993","journal-title":"Plastic and Reconstructive Surgery"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2001.119524"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24429"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyad048"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.33094"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.12.2427"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.26551"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.23838\/pfm.2022.00037"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019\u20100693"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2019.04.03"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081972"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2016.04.002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513870"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000002515"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0360\u20103016(00)00799\u20109"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.28241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:00:51Z","timestamp":1772985651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/hed.28241"],"URL":"https:\/\/doi.org\/10.1002\/hed.28241","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"2025-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}