{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:00:10Z","timestamp":1772996410340,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral tongue squamous cell carcinoma (OTSCC) incidence is rising in the United States. While early\u2010stage (pT1\u20102N0M0) OTSCC is primarily managed with surgery, the role of postoperative radiotherapy (PORT) remains debated, particularly in moderate\u2010to\u2010poor differentiation. Current guidelines do not recommend PORT based on histologic grade alone, yet a retrospective study by Tian et\u00a0al. found PORT improved survival in moderately\u2010to\u2010poorly differentiated OTSCC in a Chinese cohort. We aimed to validate these findings in a US population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study using the National Cancer Database (2004\u20132022) identified patients with pT1\u20102N0M0 OTSCC treated with surgery or surgery plus PORT. After stringent inclusion criteria, 3562 patients remained, including 456 (12.8%) who received PORT. Propensity score matching (PSM) balanced key prognostic factors, and survival was assessed using Kaplan\u2013Meier analysis and multivariable Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PORT did not improve OS in well\u2010 or moderately differentiated tumors. However, in poorly differentiated tumors, PORT was associated with a significant survival benefit (HR: 0.53, 95% CI: 0.30\u20130.92,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025) before and after PSM. This effect persisted in multivariable analysis (HR: 0.56, 95% CI: 0.31\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and after excluding patients with lymphovascular invasion (HR: 0.48, 95% CI: 0.27\u20130.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings validate and extend prior international data, demonstrating a PORT\u2010associated survival benefit in poorly differentiated early\u2010stage OTSCC. The lack of benefit in well\u2010 and moderately differentiated tumors underscores the need for individualized treatment approaches. Prospective studies are warranted to refine risk stratification and optimize clinical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28243","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T12:13:51Z","timestamp":1752495231000},"page":"3268-3274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant Radiotherapy for Early\u2010Stage Oral Tongue Cancer: Insights From the\n                    <scp>NCDB<\/scp>\n                    Based on Grade"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5939-3474","authenticated-orcid":false,"given":"Bryan","family":"Nolasco","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Patrik","family":"Brodin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Montefiore Einstein Comprehensive Cancer Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Samuel","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine and Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Schiff","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhur","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Montefiore Einstein Comprehensive Cancer Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafi","family":"Kabarriti","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Montefiore Einstein Comprehensive Cancer Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221098011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs\u20103359293\/v1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6915a1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soi.2024.100055"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032641"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032646"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.08.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28093"},{"key":"e_1_2_10_11_1","article-title":"Advances in Head and Neck Cancers: Nasopharyngeal and Oral Cancers","volume":"23","author":"National Comprehensive Cancer Network","year":"2025","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01106"},{"key":"e_1_2_10_13_1","unstructured":"National Cancer Database (NCDB).2024."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1214\/09-STS313"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3863"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_389810"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.28243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:00:55Z","timestamp":1772985655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/hed.28243"],"URL":"https:\/\/doi.org\/10.1002\/hed.28243","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"2025-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}