{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:59:49Z","timestamp":1772996389379,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001230","name":"Macquarie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Head and neck cancer treatments can cause head and neck lymphoedema (HNL), impacting quality of life (QoL). This study examined lymphatic drainage changes in HNL using Indocyanine Green Lymphography (ICG\u2010L) and assessed QoL, physical, and functional outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty individuals with HNL and 10 healthy controls completed the Lymphedema Symptom Intensity and Distress survey, bioimpedance spectroscopy (BIS), skin assessments, percent water content, and ICG\u2010L. Analysis included non\u2010parametric and Kruskal\u2010Wallis tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ICG\u2010L showed preserved original lymphatic drainage in non\u2010surgical and unilaterally treated individuals, while bilateral treatment disrupted original pathways, prompting compensatory drainage. Individuals with HNL reported significantly higher scores in soft tissue sensation, neurological symptoms, and biobehavioral symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Skin assessments revealed swelling and fibrosis. Significant differences were observed in lymphatic dysfunction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), BIS\u2010derived skeletal muscle mass percent (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015), and phase angle (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the symptom burden and altered lymphatic drainage in HNL, with ICG\u2010L showing potential for refining management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28252","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:29:43Z","timestamp":1753349383000},"page":"3372-3384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing Head and Neck Cancer\u2010Related Lymphoedema Using Indocyanine Green Lymphography\u2014A Pilot Study"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-712X","authenticated-orcid":false,"given":"Katrina","family":"Gaitatzis","sequence":"first","affiliation":[{"name":"Australian Lymphoedema Education, Research &amp; Treatment (ALERT) Centre, Department of Health Sciences Faculty of Medicine, Health and Human Sciences, Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7427-9986","authenticated-orcid":false,"given":"Belinda","family":"Thompson","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research &amp; Treatment (ALERT) Centre, Department of Health Sciences Faculty of Medicine, Health and Human Sciences, Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Suami","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research &amp; Treatment (ALERT) Centre, Department of Health Sciences Faculty of Medicine, Health and Human Sciences, Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona Tisdall","family":"Blake","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research &amp; Treatment (ALERT) Centre, Department of Health Sciences Faculty of Medicine, Health and Human Sciences, Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Heydon\u2010White","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research &amp; Treatment (ALERT) Centre, Department of Health Sciences Faculty of Medicine, Health and Human Sciences, Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puma","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"Radiation Oncology Network, Western Sydney Local Health District  Sydney Australia"},{"name":"GenesisCare, Macquarie University Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dion","family":"Forstner","sequence":"additional","affiliation":[{"name":"GenesisCare, Macquarie University Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Koelmeyer","sequence":"additional","affiliation":[{"name":"Australian Lymphoedema Education, Research &amp; Treatment (ALERT) Centre, Department of Health Sciences Faculty of Medicine, Health and Human Sciences, Macquarie University  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2016.0001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27136"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12134"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0090"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23084"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.03.019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2021.0100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814558402"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"109","article-title":"Secondary Lymphedema After Head and Neck Cancer Therapy: A Review","volume":"51","author":"Anand A.","year":"2018","journal-title":"Lymphology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2017.0024"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6192-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2022.08.017"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05661-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.REO.0000000000000322"},{"issue":"1","key":"e_1_2_10_17_1","first-page":"28","article-title":"Lymphatic Drainage Patterns in Head and Neck Lymphoedema: A Preliminary Imaging Study With Indocyanine Green Lymphography","volume":"18","author":"Pigott A.","year":"2023","journal-title":"Journal of Lymphoedema"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533614568155"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.05.008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27476"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101185"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2020.1154"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.49"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1788-1_16"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-010-0016-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-11-27"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2006.07.005"},{"key":"e_1_2_10_28_1","first-page":"1","article-title":"Patient\u2010Reported Outcome Measures and Physical Function Following Head and Neck Lymphedema\u2014A Systematic Review","author":"Gaitatzis K.","year":"2024","journal-title":"Journal of Cancer Survivorship"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31816aa072"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1667362"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2020.0071"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446117"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2014010130"},{"key":"e_1_2_10_35_1","unstructured":"ImpediMed \u201cSOZO Digital Health Platform \u201dBodyCompTM Analysis 2022 https:\/\/www.impedimed.com\/wp\u2010content\/uploads\/2021\/06\/PM\u2010117\u2010OUS\u2010BodyComp\u2010Reference\u2010Ranges\u2010Rev\u2010F_DIGITAL.pdf."},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00049-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051338"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.12.014"},{"key":"e_1_2_10_40_1","volume-title":"StatPearls","author":"Antunes C.","year":"2024"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01112"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.23.3181"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.1.81"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283393799"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.11.019"}],"container-title":["Head &amp; 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