{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:44Z","timestamp":1782748004003,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004897","name":"European Organisation for Research and Treatment of Cancer","doi-asserted-by":"publisher","award":["010\u20102016"],"award-info":[{"award-number":["010\u20102016"]}],"id":[{"id":"10.13039\/501100004897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Because salivary gland cancers (SGC) are rare and include different tumor subtypes, data on their long\u2010term quality of life and late toxicities are sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multi\u2010national study including SGC survivors more than 5\u2009years after diagnosis. They completed the European Organisation for Research and Treatment of Cancer (EORTC) quality of life core questionnaire together with its head and neck cancer module and reported problems that were most bothering for them. Toxicity was clinically assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether, 60 survivors from nine countries participated and reported\n                      <jats:italic>dry mouth<\/jats:italic>\n                      (mean score 37.2),\n                      <jats:italic>use of painkillers<\/jats:italic>\n                      (35.0),\n                      <jats:italic>problems with sexuality<\/jats:italic>\n                      (30.1),\n                      <jats:italic>insomnia<\/jats:italic>\n                      (28.9),\n                      <jats:italic>fatigue<\/jats:italic>\n                      (27.8),\n                      <jats:italic>trismus<\/jats:italic>\n                      (24.9), and\n                      <jats:italic>sticky saliva<\/jats:italic>\n                      (23.3). The most frequently mentioned long\u2010term problem was\n                      <jats:italic>dry mouth<\/jats:italic>\n                      , mentioned by a third of all participants. The most frequent toxicities were\n                      <jats:italic>hearing impairment<\/jats:italic>\n                      ,\n                      <jats:italic>soft tissue fibrosis<\/jats:italic>\n                      ,\n                      <jats:italic>dry mouth<\/jats:italic>\n                      , and\n                      <jats:italic>cranial neuropathies<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dry mouth is a frequent and disturbing problem in SGC survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28263","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T11:05:27Z","timestamp":1754046327000},"page":"13-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Late Toxicity and Long\u2010Term Quality of Life in Survivors of Cancer of the Major Salivary Glands More Than 5\u2009Years After Diagnosis: A Multi\u2010National Study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7964","authenticated-orcid":false,"given":"Susanne","family":"Singer","sequence":"first","affiliation":[{"name":"Department of Quality of Life in Oncology, Comprehensive Cancer Center Mecklenburg\u2010Vorpommern (CCC\u2010MV) University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-8085","authenticated-orcid":false,"given":"Cecilie Delphin","family":"Amdal","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital  Oslo Norway"},{"name":"Department of Research Support Services Oslo University Hospital  Oslo 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