{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:44Z","timestamp":1782748004098,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Solid subtype of papillary thyroid carcinoma (SSPTC) is an uncommon subtype of papillary thyroid cancer (PTC) and its prognostic significance is still controversial. The aim of this review is to present the clinicopathological features of SSPTC and compare its clinical behavior with classical PTC (cPTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients who underwent thyroidectomy for SSPTC and compared the clinicopathological findings and clinical outcomes with those of patients with cPTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4937 patients treated for PTC, 63 (1.3%) were diagnosed with SSPTC, of which 76.2% were female, with a median age of 40\u2009years, 3.2% had prior cervical irradiation, and the median diameter of the tumor was 15\u2009mm. Compared to cPTCs, SSPTCs were larger (median tumor diameter: 15 vs. 9\u2009mm), more symptomatic (non\u2010incidentally discovered) and were associated with an elevated risk for multifocality, extrathyroidal extension, lympho\u2010vascular invasion, lymph node metastasis, extra\u2010nodal extension, and distant metastasis. After a mean follow\u2010up of 58.5\u2009months, rates of biochemical incomplete response to treatment and structural recurrence were higher when compared to those of cPTC. None of the patients who demonstrated an excellent response to treatment presented cancer recurrence during follow\u2010up. Distant metastasis occurred in 3 patients (4.8%). There were no cancer\u2010related deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SSPTC is an aggressive histological subtype of PTC associated with adverse prognostic features, including larger tumor size, multifocality, and extrathyroidal extension, which correlate with a higher risk of cancer recurrence and therefore should be considered for accurate risk stratification, comprehensive management, and close follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.28266","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T13:59:24Z","timestamp":1753797564000},"page":"5-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance of Solid Subtype of Papillary Thyroid Carcinoma: Analysis of 63 Patients"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3630-8990","authenticated-orcid":false,"given":"Andre","family":"Ywata de Carvalho","sequence":"first","affiliation":[{"name":"Head and Neck Surgery and Otorhinolaryngology Department A. C. Camargo Cancer Center  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe D' Almeida","family":"Costa","sequence":"additional","affiliation":[{"name":"Pathology Department A. C. Camargo Cancer Center  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Guilherme","family":"Vartanian","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery and Otorhinolaryngology Department A. C. Camargo Cancer Center  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-156X","authenticated-orcid":false,"given":"Luiz Paulo","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery and Otorhinolaryngology Department A. C. Camargo Cancer Center  Sao Paulo Brazil"},{"name":"Head and Neck Surgery Department University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(19981215)83:12<2638::aid\u2010cncr31>3.0.co;2\u20101"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.07.008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_10_7_1","volume-title":"Endocrine and Neuroendocrine Tumors","author":"WHO Classification of Tumors Editorial Board","year":"2022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010022\u201003146\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19850215)55:4<805::aid\u2010cncr2820550419>3.0.co;2\u2010z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1385\/ep:16:4:323"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200112000\u201000002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19940715)74:2<748::aid\u2010cncr2820740231>3.0.co;2\u2010h"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102559.1992.tb00963.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12307"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ19\u20100414"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2022.1553"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0178"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010020\u201001391\u20101"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2021.151737"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25123"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20101533"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.034"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab445"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359\u20104292\u20102022\u20100506"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29887"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.28266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.28266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:23:08Z","timestamp":1782746588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.28266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/hed.28266"],"URL":"https:\/\/doi.org\/10.1002\/hed.28266","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]},"assertion":[{"value":"2025-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}