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At induction, blink reflexes were diminished by low\u2010dose thiopental (1\u20101.5 mg\/kg) and abolished by high\u2010dose thiopental (4\u20108 mg\/kg) and methohexital (1.5 mg\/ kg). Blink reflexes were absent during halogenated vo\/itile inhalational anesthesia and did not return until patients were in the recovery room, well after end\u2010tidal anesthetic levels were zero by mass spectroscopy. Recovery of consciousness and the ability to blink on command often preceded return of any blink reflex activity, indicating that the blink reflex is not useful as a postoperative test of facial nerve function in the operating room after anesthesia. In six patients, blink reflexes were still diminished 2\u20103 hours after cessation of anesthesia, at a time when patients were fully oriented and corneal and eyelid reflexes were clinically normal. This finding suggests that the blink reflex might be a sensitive test of subtle CNS dysfunction after inhalational anesthesia and potentially could serve as a useful objective indicator of recovery from anesthesia for outpatient surgery.<\/jats:p>","DOI":"10.1002\/hed.2880110207","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:09:07Z","timestamp":1172092147000},"page":"137-149","source":"Crossref","is-referenced-by-count":14,"title":["Effects of general anesthesia on the human blink reflex"],"prefix":"10.1002","volume":"11","author":[{"given":"Russell A.","family":"Marelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen 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