{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:10:20Z","timestamp":1773029420366,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6348,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An extensive historical review of branchial cleft cyst carcinoma is undertaken and a critical analysis of all 67 cases reported in the English literature since Martin's landmark report is carried out and tabulated. Forty\u2010one of the 67 cases were definitely ruled out as carcinomas of branchial cysts. Though only eight of the remaining 26 cases satisfied Martin's criterion of 5\u2010year follow\u2010up without evidence of primary carcinoma elsewhere, 14 patients had incontrovertible evidence of branchiogenic carcinoma, evidenced by a branchial cyst with histologic evidence of epithelial dysplasia progressing to squamous cell carcinoma within the cyst wall. Two previously unreported cases are presented. A therapeutic approach including wide local excision, radical neck dissection, and radiotherapy is recommended. A more thorough search for an occult head and neck primary, and a clearer understanding of the histopathology of branchiogenic carcinoma, are suggested as alternate requirements for this diagnosis.<\/jats:p>","DOI":"10.1002\/hed.2880110209","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:09:07Z","timestamp":1172092147000},"page":"153-163","source":"Crossref","is-referenced-by-count":75,"title":["Primary branchiogenic carcinoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Rene A.","family":"Khafif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Prichep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Minkowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"49","article-title":"Das tief Branchiogenic Halscarcinom","volume":"9","author":"Volkmann R","year":"1882","journal-title":"Zentrabl Chir"},{"key":"e_1_2_1_3_2","volume-title":"Tumours\u2014Innocent and Malignant","author":"Button JB","year":"1893"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-192907000-00001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800145411"},{"key":"e_1_2_1_6_2","first-page":"15","article-title":"Malignant epithelial tumours of the neck","volume":"23","author":"Oliver RL","year":"1935","journal-title":"Am J Cancer"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00000658-192802000-00004","article-title":"Branchial anomalies and neoplasms","volume":"87","author":"Carp L","year":"1928","journal-title":"Ann Surg"},{"key":"e_1_2_1_8_2","first-page":"703","article-title":"Branchial carcinoma","volume":"60","author":"Crile G","year":"1935","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_9_2","first-page":"507","article-title":"Results of treatment of tumours of branchiogenic origin","volume":"48","author":"Schreiner BF","year":"1929","journal-title":"Surg Gynecol Obstetr"},{"key":"e_1_2_1_10_2","volume-title":"The Spread of Tumours in the Human Body","author":"Willis RA","year":"1934"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195011000-00002"},{"key":"e_1_2_1_12_2","first-page":"673","article-title":"Metastatic neoplasms to the head and neck","volume":"133","author":"Batsakis JG","year":"1971","journal-title":"Surg Gynecol Obstetr"},{"key":"e_1_2_1_13_2","first-page":"311","article-title":"Does branchiogenic carcinoma really exist?","volume":"100","author":"Compagno JV","year":"1976","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(66)90320-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348946907800321"},{"key":"e_1_2_1_16_2","first-page":"267","article-title":"Lateral cervical (branchial) cysts and fistulas; 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