{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:09:53Z","timestamp":1707696593831},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6103,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A study of the tumor\u2014host interaction was conducted in 30 patients with nasopharyngeal carcinoma (NPC). The local immune reaction was investigated by an immunoperoxidase technique using monoclonal antibodies. Eighteen patients who were clinically suspected to have NPC, but finally proved otherwise, served as controls. There was a significant difference between the number of NPC patients with interleukin\u20102 receptor (IL\u20102R)\u2010positive cells (activated T lymphocytes) in the stroma compared with the control. IL\u20102R positive cells were found in 67% of NPC patients but in only 22% of controls (<jats:italic>P<\/jats:italic>&lt; 0.01). There was a greater infiltration of T lymphocytes in patients with a good outcome compared with patients with a poor outcome. This trend was observed in both the parenchyma (60.2 versus 29.4 \u00d7 10<jats:sup>4<\/jats:sup>cells\/mm<jats:sup>2<\/jats:sup>) and the stroma (74.7 versus 44.8 \u00d7 10<jats:sup>4<\/jats:sup>cells\/mm<jats:sup>2<\/jats:sup>). The levels of Leu\u20103 positive cells (helper\/inducer) in the NPC parenchyma were inversely correlated to the extent of the primary tumor, but there was no correlation in the stroma. These findings demonstrate that a local host\u2010immune reaction does exist and may be a useful prognostic indicator for NPC patients.<\/jats:p>","DOI":"10.1002\/hed.2880110606","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:13:51Z","timestamp":1172092431000},"page":"505-510","source":"Crossref","is-referenced-by-count":7,"title":["Local immune reaction in nasopharyngeal carcinoma, with special reference to its prognostic evaluation"],"prefix":"10.1002","volume":"11","author":[{"given":"Mow\u2010Ming","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hey\u2010Chi","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis T.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"289","article-title":"The survival of patients with nasopharyngeal carcinoma","volume":"90","author":"Hsu MM","year":"1982","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_1_3_2","first-page":"984","article-title":"A prospective study of antibodies to Epstein\u2010Barr virus DNase and viral capsid antigen for prognostication of patients with nasopharyngeal carcinoma","volume":"87","author":"Hsu MM","year":"1988","journal-title":"J Formosan Med Assoc"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910180202"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800412"},{"key":"e_1_2_1_6_2","first-page":"14","article-title":"Response of lymphocyte subpopulations to phytohemagglutinin, concanavalin A and pokeweed mitogen in patients with nasopharyngeal carcinoma","volume":"18","author":"Hsu MM","year":"1985","journal-title":"Chin J Microbiol Immunol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(80)90054-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900409"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1288\/00005537-198205000-00009","article-title":"Lymphoepithelioma of the nasopharynx","volume":"92","author":"Applebeaum EL","year":"1982","journal-title":"Laryngoscope"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1979.274"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2456::AID-CNCR2820531116>3.0.CO;2-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988609500203"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890090503"},{"key":"e_1_2_1_14_2","first-page":"32","volume-title":"International histological typing of tumors, No. 19","author":"Shanmugaratnum K","year":"1978"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(80)90052-8"},{"key":"e_1_2_1_16_2","first-page":"4053","article-title":"Lymphoid cell subpopulations infiltrating into autologus rat tumors undergoing rejection","volume":"44","author":"Ishii Y","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_17_2","first-page":"79","article-title":"Functional analysis of monoclonal cells infiltrating into tumors: Differential cytotoxicity of mononuclear cells from tumors of immune and non\u2010immune rats","volume":"33","author":"Ibayashi Y","year":"1985","journal-title":"J Immunol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488609108618"},{"key":"e_1_2_1_19_2","volume-title":"Product Discription of Murine monoclonal antibody to human interleukin\u20102 receptor","year":"1986"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910390602"},{"key":"e_1_2_1_21_2","first-page":"2188","article-title":"In vivo administration of purified human interleukin\u20102 to patients with cancer: Development of interleukin\u20102 receptor positive cells and circulating soluble interleukin\u20102 receptors following interleukin\u20102 administration","volume":"47","author":"Lotze MT","year":"1987","journal-title":"Cancer Res"}],"container-title":["Head &amp; 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