{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:51:15Z","timestamp":1792057875722,"version":"4.4.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5922,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A retrospective review of 333 previously untreated patients from 1965 to 1986, with primary squamous cell carcinoma of the oropharynx or hypopharynx, was undertaken to ascertain the prevalence of neck node metastases by neck level. The 333 patients underwent 344 classical radical neck dissections. Patients were grouped by clinical neck status at the time of neck dissection: elective dissection in the NO neck (N = 71), and immediate therapeutic dissection in the N+ neck (N = 259). Detailed analysis was performed for each group based on the specific primary site. This revealed a predominance of neck node metastases in levels II, III, and IV for both oropharyngeal and hypopharyngeal primaries. Isolated \u201cskip\u201d metastases outside of levels II, III, or IV occurred in only 1 patient (0.3%). Otherwise, level I or V involvement was always associated with nodal metastases at other levels (ie, N2 disease). These data support the trend toward selective limited neck dissection (anterior modified) in NO patients. Furthermore, they provide the foundation for planning of future prospective trials to assess the efficacy of modifications in the extent of neck dissection for carcinomas of the oropharynx or hypopharynx.<\/jats:p>","DOI":"10.1002\/hed.2880120302","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:44:13Z","timestamp":1172094253000},"page":"197-203","source":"Crossref","is-referenced-by-count":219,"title":["Patterns of cervical node metastases from squamous carcinoma of the oropharynx and hypopharynx"],"prefix":"10.1002","volume":"12","author":[{"given":"Frank C.","family":"Candela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Kothari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1906.25210220006001a"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198407000-00015"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(85)90146-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890100304"},{"key":"e_1_2_1_6_2","first-page":"33","volume-title":"American Joint Committee on Cancer. Manual for staging of cancer","year":"1988"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0007-1226(81)90110-7"},{"key":"e_1_2_1_8_2","first-page":"159","article-title":"Lo svuotamento funzionale laterocervicale. Basi anatomich","volume":"4","author":"Teatini GP","year":"1976","journal-title":"Nuovo Arch It Otol"},{"key":"e_1_2_1_9_2","unstructured":"TruffertP. Le cou les aponeuroses les loges Amette Paris 1922."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80293-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600604"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780060047002"},{"key":"e_1_2_1_13_2","first-page":"83","article-title":"El problema de las metastasis linfaticas del cancer de laringe and hipofaringe","volume":"22","author":"Suarez A","year":"1963","journal-title":"Rev Otorrinolaringol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100106553"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880120302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880120302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880120302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:21:25Z","timestamp":1695493285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880120302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1002\/hed.2880120302"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880120302","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}