{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:01:17Z","timestamp":1767837677731,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5922,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From September 1983 to September 1987, 238 patients with squamous cell carcinoma of the upper aerodigestive tract were given 3 cycles of chemotherapy [cisplatinum (cis\u2010DDP), 100 mg\/m<jats:sup>2<\/jats:sup> on day 1; 5\u2010fluorouracil (5\u2010FU), 1,000 mg\/m<jats:sup>2<\/jats:sup> on days 2\u20106] before any local treatment. Eighty\u2010one of these patients had pharyngolaryngeal cancer. Of the 45 of 50 laryngeal cancers and 26 of 31 hypopharyngeal cancers suitable for evaluation, complete responses (CR) were obtained in 51.1% and 53.8%, respectively. These response rates led to changes in the postchemotherapy protocols. For CRs, mutilating surgical protocols were replaced by definitive radiotherapy: one local recurrence has been observed among the 9 laryngeal cancers, and 3 of 10 hypopharyngeal cancer patients, who had an initial indication of total laryngectomy or total pharyngolaryngectomy replaced by radiotherapy. In the group of CR, survival rates at 2 years were 93% and 69%, respectively, for the larynx and hypopharynx vs 65.6% and 40% for non\u2010CR patients. The possibility of conservative treatment sparing vocal function with a high degree of reliability would in itself appear to be justification for induction chemotherapy in pharyngolaryngeal cancers, even though its long\u2010term effects remain controversial.<\/jats:p>","DOI":"10.1002\/hed.2880120306","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:44:13Z","timestamp":1172094253000},"page":"225-231","source":"Crossref","is-referenced-by-count":35,"title":["Response to chemotherapy as justification for modification of the therapeutic strategy for pharyngolaryngeal carcinomas"],"prefix":"10.1002","volume":"12","author":[{"given":"Fran\u00e7ois","family":"Demard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Chauvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Santini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Vallicioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Thyss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"150","article-title":"Preoperative vs postoperative radiation therapy in advanced squamous cell carcinoma of the head and neck:Final report on the study 73\u201003 of the RTOG","volume":"6","author":"Kramer S","year":"1983","journal-title":"Am J Clin Oncol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060305"},{"key":"e_1_2_1_4_2","first-page":"343","article-title":"Distant metastasis from head and neck cancer","volume":"53","author":"Papal A","year":"1984","journal-title":"Cancer"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197401)33:1<127::AID-CNCR2820330119>3.0.CO;2-L"},{"key":"e_1_2_1_6_2","first-page":"567","article-title":"Chimioth\u00e9rapie premi\u00e8re associant vincristine, bl\u00e9omycine, m\u00e9thotrexate et cisplatine par voie syst\u00e9mique ou intraart\u00e9rielle dans les cancers des voies a\u00e9ro\u2010digestives sup\u00e9rieures","volume":"100","author":"Demard F","year":"1983","journal-title":"Ann Otolaryngol (Paris)"},{"key":"e_1_2_1_7_2","first-page":"285","article-title":"Chimioth\u00e9rapie intraart\u00e9rielle des tumeurs ORL. Dixans d'exp\u00e9rience au Centre Antoine\u2010Lacassagne","volume":"102","author":"Demard F","year":"1985","journal-title":"Ann Otolaryngol (Paris)"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.237"},{"key":"e_1_2_1_9_2","first-page":"399","article-title":"Chimioth\u00e9rapie d'induction platine\u20105\u2010fluorouracile. R\u00e9sultats actuels en canc\u00e9rologie cervicohfaciale","volume":"104","author":"Demard F","year":"1987","journal-title":"Ann Otolaryngol (Paris)"},{"key":"e_1_2_1_10_2","first-page":"109","volume-title":"La Chimioth\u00e9rapie dans les cancers des voies a\u00e9ro\u2010digestives sup\u00e9rieurs, Actualit\u00e9s de Carcinologie Cervico\u2010faciale","author":"Chauvel P","year":"1987"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840901)54:5<811::AID-CNCR2820540508>3.0.CO;2-E"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870915)60:6<1178::AID-CNCR2820600604>3.0.CO;2-S"},{"key":"e_1_2_1_13_2","first-page":"130","article-title":"The VA Cooperative Studies Program: A new strategy to preserve the larynx in the treatment of advanced laryngeal cancer. Preliminary report","volume":"6","author":"Hong WK","year":"1987","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90473-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.5.672"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.3.456"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880120306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880120306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880120306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:21:39Z","timestamp":1695493299000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880120306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1002\/hed.2880120306"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880120306","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}