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Sixty\u2010five patients received radiotherapy to the neck and at least part of the mucosa of the head and neck, whereas 4 patients received treatment to the neck only. Mucosal doses were approximately 5,000 cGy\u20106,000 cGy at 170 cGy\u2010180 cGy per fraction. Eight patients (12%) subsequently developed mucosal site failures, a figure that did not differ significantly from the incidence of a second metachronous head and neck cancer following definitive irradiation in a series of 393 patients with lesions of the supraglottic larynx, pharyngeal wall, pyriform sinus, or tonsillar area. This suggests that radiotherapy was highly effective in preventing the appearance of cancer at the unknown primary site from which the neck metastasis arose. Absolute and cause\u2010specific 5\u2010year survival rates were 48% and 66%, respectively.<\/jats:p>","DOI":"10.1002\/hed.2880120603","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:40:52Z","timestamp":1172094052000},"page":"463-469","source":"Crossref","is-referenced-by-count":67,"title":["Cancer in neck nodes with unknown primary site: Role of mucosal radiotherapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Christopher S.","family":"Harper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott P.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Cassisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney R.","family":"Million","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198709000-00015"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90008-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/110.3.659"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.5.645"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198104000-00012"},{"key":"e_1_2_1_7_2","first-page":"231","volume-title":"Management of head and neck cancer: a multidisciplinary approach","author":"Million RR","year":"1984"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197304)31:4<854::AID-CNCR2820310414>3.0.CO;2-D"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1952.11694298"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.152.3.6463256"},{"key":"e_1_2_1_11_2","first-page":"27","volume-title":"Manual for staging of cancer","author":"American Joint Committee on Cancer","year":"1983"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90030-7"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_14_2","first-page":"529","volume-title":"SAS user's guide: Statistics","year":"1985"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.12.1443"},{"key":"e_1_2_1_16_2","first-page":"636","volume-title":"Principles and practice of radiation oncology","author":"Mendenhall WM","year":"1987"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(87)80066-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(88)90002-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(87)80231-1"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120303"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197555030-00021"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(84)90294-3"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(85)90331-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90030-1"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880120603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880120603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T17:32:10Z","timestamp":1697995930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880120603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1002\/hed.2880120603"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880120603","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}