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Patients were staged according to the AJCC system and by the modality of neoplastic involvement of AC (pure AC cancer, glottic cancer involving AC up to the midline, and beyond the midline). Our results indicate a higher rate of local control and of specific\u2010disease survival in the group of patients first treated with surgery than those treated with radiotherapy (86% vs 74% and 97.5% vs 84%, respectively) (p &lt; 0.05). For pure AC cancers, our results show better local control with primary radiotherapy than with conservation surgery (82% vs 76.5%), but surgical failures have been more successfully salvaged than have radiotherapy recurrences (ultimate local control, 97.5% vs 82%, respectively). These data suggest that the treatment of choice for AC cancers is conservation surgery, particularly frontolateral laryngectomy.<\/jats:p>","DOI":"10.1002\/hed.2880130505","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:50:57Z","timestamp":1172094657000},"page":"403-410","source":"Crossref","is-referenced-by-count":58,"title":["Glottic cancer involving anterior commissure: Surgery vs radiotherapy"],"prefix":"10.1002","volume":"13","author":[{"given":"Lucio","family":"Rucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oreste","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omero","family":"Fini\u2010Storchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"625","article-title":"The anterior commissure revisited","volume":"82","author":"Tucker GF","year":"1973","journal-title":"Ann Otol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109133252"},{"key":"e_1_2_1_4_2","first-page":"18","article-title":"Vasculature of the anterior commissure","volume":"90","author":"Andrea M","year":"1981","journal-title":"Ann Otol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198303000-00020"},{"key":"e_1_2_1_6_2","first-page":"676","volume-title":"Anterior commissure cancer","author":"Kirchner JA","year":"1976"},{"key":"e_1_2_1_7_2","first-page":"503","article-title":"Intralaryngeal barriers to the spread of cancer","volume":"103","author":"Kirchner JA","year":"1987","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"e_1_2_1_8_2","unstructured":"NicelliF.II cancro della commessura anteriore della laringe.Arch Ital Otol1953;(suppl 14):152\u2013163."},{"key":"e_1_2_1_9_2","first-page":"37","volume-title":"Manual for staging of cancer","author":"American Joint Committee on Cancer","year":"1983"},{"key":"e_1_2_1_10_2","first-page":"13","volume-title":"Manual for staging of cancer","author":"American Joint Committee on Cancer","year":"1988"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1970.00770040754006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1972.00770080372009"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/103.3.663"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197506000-00008"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197510000-00002"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197509000-00007"},{"key":"e_1_2_1_17_2","first-page":"467","article-title":"Primary radiotherapy for in situ carcinoma of the glottic larynx","volume":"5","author":"Sung DI","year":"1979","journal-title":"IJOBP"},{"key":"e_1_2_1_18_2","first-page":"811","article-title":"Early glottic carcinoma: factors affecting radiation failure, results of treatment and sequelae","volume":"5","author":"Mills EED","year":"1979","journal-title":"IJROBP"},{"key":"e_1_2_1_19_2","first-page":"473","article-title":"Radiotherapy of early glottic cancer","volume":"5","author":"Harwood AR","year":"1979","journal-title":"IJROBP"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198107000-00014"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830315)51:6<994::AID-CNCR2820510605>3.0.CO;2-F"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198302000-00019"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.149.1.6611940"},{"key":"e_1_2_1_24_2","first-page":"997","article-title":"Role of radiation in the management of early vocal cord carcinoma","volume":"9","author":"Mittal B","year":"1983","journal-title":"IJROBP"},{"key":"e_1_2_1_25_2","first-page":"1333","article-title":"The influence of field size, treatment modality, commissure involvement and histology in the treatment of early vocal cord cancer with irradiation","volume":"11","author":"Olszewski SJ","year":"1985","journal-title":"IJROBP"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868509136059"},{"key":"e_1_2_1_27_2","first-page":"313","article-title":"Heterogeneity of stage II glottic carcinoma and its therapeutic implications","volume":"13","author":"Karim ABMF","year":"1987","journal-title":"IJROBP"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890100603"},{"key":"e_1_2_1_29_2","first-page":"451","article-title":"The effect of fraction size on control of early glottic cancer","volume":"14","author":"Schwaibold F","year":"1988","journal-title":"IJROBP"},{"key":"e_1_2_1_30_2","first-page":"1199","article-title":"Radiation therapy for early glottic cancer (TIN0M0). Results of conventional open field technique","volume":"17","author":"Teshima T","year":"1989","journal-title":"IJROBP"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909125556"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(89)90076-5"},{"key":"e_1_2_1_33_2","unstructured":"ShvihiY ZoharY RahimaM. Cancer of the anterior commissure of the larynx\u2014irradiation versus conservative surgery. 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