{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:16:23Z","timestamp":1753182983202},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5434,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with advanced carcinomas of the hypopharynx or upper esophagus have among the worst prognoses in head and neck oncology. We developed a treatment regimen of rapidly alternating multi\u2010agent chemotherapy and accelerated interrupted radiotherapy as follows: Three cycles of chemotherapy were delivered [day 1, cisplatin 100 mg\/m<jats:sup>2<\/jats:sup>; days 1\u20104, 5\u2010fluorouracil (5\u2010Fu) 900 mg\/m<jats:sup>2<\/jats:sup>] and repeated every 3 weeks. On day 8 of each chemotherapy cycle radiotherapy was started, consisting of 10 fractions of 200 cGy delivered twice daily, for 5 days. The total dose of radiotherapy was 6,000 cGy over 7 weeks, and the total duration of chemotherapy and radiotherapy was 8 weeks. Nineteen patients with locally advanced, epidermoid carcinoma of the hypopharynx (9 patients) or upper esophagus (10 patients) were treated on this protocol. Minimum follow\u2010up was 1 year. Twelve patients had tumors judged technically unresectable, whereas 7 had tumors considered resectable only with total laryngectomy, which was unacceptable to the patients. One patient died of nadir sepsis during treatment, but otherwise the acute toxicity was relatively mild (grade I\/II in 16 patients, grade III\/IV in 3 patients). The complete response rate was 83% (15 of 18 patients), and the partial response rate was 17% (3 of 18). No patient failed to respond. The survival rate was 80% at 1 year and 73% at 18 months. At 1 year, 89% of the patients remained in remission and at 18 months, 74%. Late complications occurred in 4 patients. These included laryngeal necrosis, pneumonitis, esophageal stricture, and tracheoesophageal fistula. Our experience suggests that this regimen is quite useful in cancers of the hypopharynx and upper esophagus and deserves further investigation.<\/jats:p>","DOI":"10.1002\/hed.2880130507","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:50:57Z","timestamp":1172094657000},"page":"415-419","source":"Crossref","is-referenced-by-count":10,"title":["Chemotherapy rapidly alternating with accelerated radiotherapy for advanced carcinomas of the hypopharynx and upper esophagus: A feasibility study"],"prefix":"10.1002","volume":"13","author":[{"given":"Bhadrasain","family":"Vikram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Malamud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Nussbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Kimmelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lucente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Pavlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julianna","family":"Pisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjeet","family":"Chadha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1533","article-title":"Cisdiammine platinum based chemotherapy as initial treatment of advanced head and neck cancer","volume":"63","author":"Wittes R","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_3_2","first-page":"145","volume-title":"Adjuvant therapy of cancer","author":"Al\u2010Sarraf M","year":"1981"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90451-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870801)60:3<301::AID-CNCR2820600306>3.0.CO;2-V"},{"key":"e_1_2_1_6_2","first-page":"98","article-title":"Randomized comparison of preoperative chemotherapy versus radiation in epidermoid esophageal cancer","volume":"7","author":"Kelsen D","year":"1988","journal-title":"Proceedings of the American Society of Clinical Oncology"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198811000-00011"},{"key":"e_1_2_1_8_2","first-page":"1421","article-title":"Combination chemotherapy used prior to radiation therapy for locally advanced squamous cell carcinoma of the head and neck","volume":"66","author":"Tannock I","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800280012005"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860070072019"},{"key":"e_1_2_1_11_2","first-page":"302","volume-title":"Head and neck cancer","author":"Tannock I","year":"1990"},{"key":"e_1_2_1_12_2","first-page":"289","article-title":"SECOG. A randomized trial of combined multi\u2010drug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck","volume":"12","year":"1986","journal-title":"Eur J Surg Oncol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.4.627"},{"key":"e_1_2_1_14_2","first-page":"351","article-title":"Combined radiotherapy and multi\u2010drug chemotherapy for advanced head and neck cancer. Results of the radiation therapy oncology group pilot study","volume":"63","author":"Fu K","year":"1979","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90612-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930150114"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1747-0_8"},{"key":"e_1_2_1_18_2","first-page":"85","article-title":"Special lecture, alternating chemotherapy and radiotherapy","volume":"8","author":"Looney WB","year":"1988","journal-title":"NCI Monogr"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00047057"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90369-5"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90381-7"},{"key":"e_1_2_1_22_2","volume-title":"Manual for staging of cancer","author":"American Joint Committee on Cancer","year":"1988"},{"key":"e_1_2_1_23_2","first-page":"361","article-title":"New strategies for avoiding total laryngectomy in patients with head and neck cancer","volume":"6","author":"Vikram B","year":"1988","journal-title":"NCI Monogr"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1200\/JCO.1989.7.4.471","article-title":"Cisplatin, fluorouracil with leucovorin calcium enhancement and synchronous accelerated radiotherapy in the management of locally advanced head and neck, a phase II study","volume":"7","author":"Wendt T","year":"1989","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880120108"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880130507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880130507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:17:27Z","timestamp":1698063447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880130507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1002\/hed.2880130507"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880130507","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}