{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:25:52Z","timestamp":1784258752605,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":5007,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Occult thyroid cancer is an occasional incidental finding during surgery for other indications and is usually considered of minor clinical significance; however, the appropriate approach for incidentally found metastatic thyroid cancer is less clear especially when it occurs in the context of another malignancy that has more aggressive potential. Among 2,855 patients treated for squamous cancer of the tongue at The University of Texas M. D. Anderson Cancer Center, eight patients had coexisting differentiated thyroid cancer metastatic to cervical lymph nodes which was found incidentally during regional lymph node dissection. The eight patients included three women and five men with a median age of 47 years (range, 32\u201062 years); tumors were of the papillary variety in four patients and follicular in the other four. In one patient, no gross or microscopic primary tumor could be identified after thyroidectomy; in another patient, no gross tumor was evident, but whole organ section revealed an area of fibrosis consistent with a primary lesion. Two patients had primary lesions less than 1 cm in maximal diameter. In four patients who had no surgery, physical exam and radiologic evaluation failed to show any intrathyroidal lesions. Clinically relevant thyroid cancer did not develop in any of those patients during the duration of documented follow\u2010up (1\u201015 years). Three patients died of progressive tongue cancer, one patient of unrelated pulmonary disease, and four patients remain alive without evidence of disease for 1 to 15 years of available follow\u2010up. We suggest that differentied thyroid cancer discovered incidentally during surgery for another, potentially more aggressive mallignancy may be approached conservatively when the thyroid gland does not demonstrate clinical or radiologic lesions. \u00a9 1992 John Wiley &amp; Sons Inc.<\/jats:p>","DOI":"10.1002\/hed.2880140606","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:47:03Z","timestamp":1172094423000},"page":"459-463","source":"Crossref","is-referenced-by-count":47,"title":["Metastatic thyroid cancer as an incidental finding during neck dissection: Significance and management"],"prefix":"10.1002","volume":"14","author":[{"given":"Rena","family":"Vassilopoulou\u2010Sellin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal S.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891101)64:9<1888::AID-CNCR2820640922>3.0.CO;2-C"},{"key":"e_1_2_1_3_2","first-page":"123","volume-title":"Radiation\u2010associated thyroid carcinomas","author":"Nishiyama RH","year":"1977"},{"key":"e_1_2_1_4_2","first-page":"137","volume-title":"Radiation\u2010associated thyroid carcinoma","author":"Sampson RJ","year":"1977"},{"key":"e_1_2_1_5_2","first-page":"141","article-title":"Occult carcinoma of the thyroid gland: an epidemiologial study of autopsy material","volume":"61","author":"Autelitano F","year":"1990","journal-title":"Ann Ital Chir"},{"key":"e_1_2_1_6_2","first-page":"971","article-title":"Not all \u201coccult\u201d papillary carcinomas are \u201cminimal.\u201d","volume":"104","author":"Allo MD","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810215)47:4<664::AID-CNCR2820470408>3.0.CO;2-#"},{"key":"e_1_2_1_8_2","first-page":"947","article-title":"An expanded view of risk \u2010 group definition in differentiated thyroid carcinoma","volume":"104","author":"Cady B","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110506"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30480-1"},{"key":"e_1_2_1_11_2","volume-title":"American Joint Committee on Cancer: Manual for staging of cancer","year":"1983"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:1<103::AID-CNCR2820200116>3.0.CO;2-S"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196103\/04)14:2<221::AID-CNCR2820140202>3.0.CO;2-6"},{"key":"e_1_2_1_14_2","first-page":"659","article-title":"Incidence of carcinoma in thyroid glands moved at 1000 consecutive routine necropsies","volume":"5","author":"Mortensen JD","year":"1954","journal-title":"Pro Surg Forum"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197705000-00001"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871201)60:11<2587::AID-CNCR2820601102>3.0.CO;2-O"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-2-133"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.2980070210"},{"key":"e_1_2_1_19_2","first-page":"488","volume-title":"Cancer principles and practice of oncology","author":"Million RR","year":"1989"},{"key":"e_1_2_1_20_2","unstructured":"DearnnaleyDP FryattI DardoufasC HenkJM.Carcinoma of tongue treated by interstitial irradiation: multivariate analysis of factors related to loco\u2010regional control and survival. In: Seventh annual meeting of the European Society for Therapeutic Radiology and Oncology 1988:469."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910315)67:6<1532::AID-CNCR2820670612>3.0.CO;2-D"},{"key":"e_1_2_1_22_2","first-page":"501","article-title":"The importance of completing a follow\u2010up\u2014its influence on survival curves","volume":"32","author":"Ogawa K","year":"1986","journal-title":"Jpn J Cancer Clin"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ssu.2980050507"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199104000-00015"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880140606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880140606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:36:41Z","timestamp":1698050201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880140606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1002\/hed.2880140606"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880140606","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}