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Surgery or irradiation alone was found to result in similar local control rates for stage I and II lesions, whereas more advanced tumors had better local control rates with a combination of surgery and irradiation. Radiotherapy had a higher incidence of minor and moderate complications, whereas a greater number of severe complications occurred after surgery. We recommend surgery for early lesions due to the lower overall incidence of associated complications. Despite a higher risk of severe complications, combination therapy is recommended for more advanced lesions due to improved local control as compared to single modality therapy.<\/jats:p>","DOI":"10.1002\/hed.2880150104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T21:46:17Z","timestamp":1172094377000},"page":"16-19","source":"Crossref","is-referenced-by-count":57,"title":["Management of squamous cell carcinoma of the floor of mouth"],"prefix":"10.1002","volume":"15","author":[{"suffix":"Jr.","given":"Lawrence W.","family":"Rodgers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott P.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Mendenhall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James T.","family":"Parsons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Cassisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney R.","family":"Million","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800616"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790310043010"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00000658-198301001-00006","article-title":"Intra\u2010oral cancer at the Massachusetts General Hospital. 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