{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:42:37Z","timestamp":1787586157941,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4703,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies of laryngeal cancer have shown a decrease in the male\u2010to\u2010female ratio and that the sex ratio in glottic tumors is higher than that for other laryngeal sites. The purpose of this study was to characterize and identify changes in the demographics, laryngeal site predilection, geographic distribution, trends in tumor stage at diagnosis, and surgical caseload distribution in Colorado. The Colorado Central Cancer Registry for the years 1979 to 1990 was reviewed for cases of laryngeal cancer. The data were analyzed using chi\u2010square and gradient\u2010in\u2010proportions methods. One\u2010thousand two\u2010hundred sixty\u2010five (1265) cases were identified with a male\u2010to\u2010female ratio of 4.3:1. There was a significant trend of an increasing proportion of cases attributable to women. Glottic carcinoma accounted for 50.1% of cases, with a male\u2010to\u2010female ratio of 7.6:1. The Denver metropolitan area accounted for 57% of all cases, which was not disproportionate to the population. From 1981 to 1990 there was a significant decrease in the proportion of stage I cases and an increase in stage II cases. The teaching hospitals associated with the University of Colorado were responsible for performing 44.5% of all surgery for laryngeal cancer. The results indicate that laryngeal cancer in Colorado shares similar epidemiologic characteristics to those reported in other studies. Of most concern is the increasing proportion of women with laryngeal cancer and the decrease in cases diagnosed at stage I.<\/jats:p>","DOI":"10.1002\/hed.2880150506","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:10:47Z","timestamp":1172095847000},"page":"398-404","source":"Crossref","is-referenced-by-count":4,"title":["Laryngeal cancer in Colorado"],"prefix":"10.1002","volume":"15","author":[{"given":"James A.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlen D.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","series-title":"BHEW Publication #(NIH)78\u20131837","volume-title":"SEER Program: cancer incidence and mortality in the United States 1973\u20131976","author":"Young J","year":"1978"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.1971.03190170031005","article-title":"Cigarette smoking and cancer of the mouth, pharynx, and larynx","volume":"218","author":"Moore C","year":"1971","journal-title":"JAMA"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(74)90037-1"},{"key":"e_1_2_1_5_2","first-page":"1219","article-title":"Tobacco, alcohol, asbestos, and nickel in the etiology of cancer of the larynx: a case control study","volume":"67","author":"Burch J","year":"1981","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_6_2","first-page":"1960","article-title":"Occupational risk factors for laryngeal cancer on the Texas Gulf Coast","volume":"48","author":"Brown L","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870180117023"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(89)90072-3"},{"key":"e_1_2_1_9_2","volume-title":"Cancer in Colorado 1979 to 1988: prevention, incidence, survival, and mortality","author":"Karp S","year":"1991"},{"key":"e_1_2_1_10_2","series-title":"NIH Publication #90\u20132789","volume-title":"Cancer statistics review\u20141973\u20131987","author":"Ries L","year":"1990"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871215)60:12<3092::AID-CNCR2820601239>3.0.CO;2-H"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(90)90047-S"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800130094013"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(69)90212-8"},{"key":"e_1_2_1_15_2","unstructured":"MendelsonB.The alcohol and drug problem in Colorado: characteristics and trends from 1980 to 1990.Colorado Alcohol and Drug Abuse Division Office of Data Analysis and Evaluation 1990."}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880150506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880150506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:53:46Z","timestamp":1698281626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880150506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/hed.2880150506"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880150506","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}