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The 5\u2010year survival was significantly related to the stage of the disease (stage I, 74%; stage II, 63%; stage III, 32%; and stage IV, 14%) and the preoperative nodal staging (NO, 57%; N1, 28%; N2, 6%; and N3, 0%), but not related to the extent of tumor resection. The local control rate was 86% and the majority of the local recurrences occurred at the upper resection margin. There was no significant difference in the local recurrence rate between those patients who had pharyngolaryngoesophagectomy and those who had pharyngolaryngectomy. However, the resection\u2010associated complications (bleeding, cardiac arrhythmia, pulmonary complications) were more frequent when total esophagectomy was performed. Reconstruction\u2010associated complications such as wound infection and anastomotic leakage occurred less often after gastric pull\u2010up reconstruction as compared with the use of myocutaneous flap, but was associated with more serious outcome after pharyngogastric anastomosis. Thirty\u2010seven patients (34%) had neck node recurrences and these were significantly related to the preoperative nodal staging (NO, 20%; N1 37%; N2, 48%; and N3, 83%). Additional primary cancers occurred in 17% of the patients and was a significant cause of death in those patients who survived more than 2 years.<\/jats:p>","DOI":"10.1002\/hed.2880150507","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:10:47Z","timestamp":1172095847000},"page":"405-412","source":"Crossref","is-referenced-by-count":68,"title":["Squamous cell carcinoma of the hypopharynx\u2014analysis of treatment results"],"prefix":"10.1002","volume":"15","author":[{"given":"Chiu Ming","family":"Ho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam Hing","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Ignace","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po Wing","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai Kun","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1987.01860010073018"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860290066016"},{"key":"e_1_2_1_4_2","first-page":"33","volume-title":"Manual for Staging of Cancer","author":"American Joint Committee on Cancer","year":"1988"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(75)90492-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90315-9"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198204000-00001"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.5.556"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890100103"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1970.hed1002088.x"},{"key":"e_1_2_1_11_2","first-page":"317","article-title":"Surgical treatment of carcinoma of the hypopharynx and cervical oesophagus","volume":"9","author":"Lam KH","year":"1980","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800560204"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100071991"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060105"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1973.00780010350013"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740218"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890030203"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060510"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800050087014"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890100713"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890100104"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:5<663::AID-CNCR2820200514>3.0.CO;2-Q"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90126-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199009203231205"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880150507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880150507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:53:48Z","timestamp":1698281628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880150507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/hed.2880150507"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880150507","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}