{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:31:13Z","timestamp":1761647473171,"version":"3.33.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic>The purpose of this study is to evaluate the survival of patients treated at the University of Virginia Health Sciences Center with an anterior craniofacial resection in conjunction with radiotherapy and\/or chemotherapy for malignancies of the superior sinonasal cavity. In addition, the impact of aggressive salvage therapy for patients with recurrent disease is considered.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic>Between June 1976 and December 1992, a total of 45 patients underwent a craniofacial resection by the Departments of Otolaryngology\u2010Head and Neck Surgery and Neurological Surgery at the University of Virginia. One patient was excluded from the analysis because his neoplasm was benign. Another patient died 2 days postoperatively from multiple strokes. The remaining 43 patients were divided into two subgroups: (1) patients with esthesioneuroblastoma (24 patients) and patients with non\u2010esthesioneuroblastoma malignancies (19). Their survival curves were estimated for the percent survival free of disease by month of follow\u2010up using the product limit of Kaplan and Meier. In addition, the salvage treatment for recurrences was examined for both groups.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic>The 5\u2010year disease\u2010free survival rate for the entire group was 77%, with a 2.3% postoperative mortality. The 5\u2010year disease\u2010free survival for the esthesioneuroblastoma patients was 90%, and that for the non\u2010esthesioneuroblastoma group was 59.1% (<jats:italic>p<\/jats:italic>= 0.028). Four of 8 esthesioneuroblastoma patients who recurred and were treated with aggressive salvage therapy were without evidence of disease 5 years after completion of therapy, and 3 of the 10 nonesthesioneuroblastoma patients salvaged were without evidence of disease 57.3 months after therapy (39% surgical salvage).<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic>There is a statistically significant difference between the 5\u2010year disease\u2010free survival for the esthesioneuroblastoma patients and the non\u2010esthesioneuroblastoma patients (90% vs 59.1%;<jats:italic>p<\/jats:italic>= 0.028), and aggressive salvage therapy appears to be a more successful option in the esthesioneuroblastoma group of patients.<\/jats:p>","DOI":"10.1002\/hed.2880160613","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:12:45Z","timestamp":1172095965000},"page":"574-577","source":"Crossref","is-referenced-by-count":45,"title":["Craniofacial resection at the university of Virginia (1976\u20101992): Survival analysis"],"prefix":"10.1002","volume":"16","author":[{"given":"Paul A.","family":"Levine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Debo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott D.","family":"Meredith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Jane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Constable","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Cantrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_2","DOI":"10.1002\/1097-0142(197603)37:3<1571::AID-CNCR2820370347>3.0.CO;2-L"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_2","DOI":"10.1288\/00005537-198607000-00008"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1288\/00005537-199011000-00013"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1001\/archotol.1992.01880090029010"},{"doi-asserted-by":"publisher","key":"e_1_2_1_6_2","DOI":"10.1177\/019459989210600412"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1177\/019459988910100609"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_2","DOI":"10.1002\/hed.2880150314"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_2","DOI":"10.1177\/019459989310800611"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_2","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables (with discussion)","volume":"34","author":"Cox D","year":"1972","journal-title":"JR Stat Soc"},{"key":"e_1_2_1_12_2","first-page":"631","volume-title":"Esthesioneuroblastoma. Textbook of uncommon cancers","author":"Williams CJ","year":"1988"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_2","DOI":"10.1001\/archotol.1988.01860180046027"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_2","DOI":"10.1177\/019459989010300312"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880160613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880160613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:30:47Z","timestamp":1736814647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880160613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1002\/hed.2880160613"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880160613","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"type":"print","value":"1043-3074"},{"type":"electronic","value":"1097-0347"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}