{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:30:05Z","timestamp":1765294205691},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4216,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> Multicystic benign lymphoepithelial lesions of the parotid gland (BLL) seen in patients with human immunodeficiency virus (HIV) can produce considerable cosmetic deformity as well as physical discomfort. We previously reported our preliminary results with low\u2010dose radiotherapy in this disease, and all 8 patients were satisfied with the initial improvement in their appearance. We now report the long\u2010term follow\u2010up of those patients and additional patients.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Twelve HIV\u2010positive patients with BLL were treated with 8\u201310 Gy of external radiation using 2\u2010Gy daily fractions. Objective responses and subjective duration of patient\u2010defined cosmetic control were recorded.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> All 12 patients (100%) had at least a 50% decrease in the size of their parotid masses. Five of 12 (42%) had a complete response and 7 (58%) had a partial response. Persisting complete response was achieved in only 1 patient, however, with relapse in the other 11 patients. Cosmetic palliation, as judged by the patients, was achieved for a median of 9.5 months. Eight patients were subsequently retreated with doses of 6\u201316 Gy (median and mode: 10 Gy). None (0%) of the 8 patients retreated achieved local control.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> Very low\u2010dose radiation (8\u201310 Gy) provides reliable but temporary cosmetic palliation for BLL. Retreatment was unsatisfactory, and we are now investigating higher initial doses of radiation to prolong palliation and eliminate recurrences. \u00a9 1995 Jons Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/hed.2880170107","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:43:21Z","timestamp":1172097801000},"page":"31-35","source":"Crossref","is-referenced-by-count":27,"title":["Low\u2010dose radiotherapy for multicystic benign lymphoepithelial lesions of the parotid gland in HIV\u2010positive patients: Long\u2010term results"],"prefix":"10.1002","volume":"17","author":[{"given":"Jonathan J.","family":"Beitler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhadrasain","family":"Vikram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John S.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin J.","family":"Mitnick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Gejerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence W.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988709700118"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(88)80297-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)90141-Y"},{"key":"e_1_2_1_5_2","first-page":"475","article-title":"Parotid disease associated with human immunodeficiency virus infection","volume":"69","author":"Sperling NM","year":"1990","journal-title":"ENT"},{"key":"e_1_2_1_6_2","first-page":"155","volume-title":"Aids: etiology, treatment, and prevention","author":"Macher AM","year":"1988"},{"key":"e_1_2_1_7_2","first-page":"821","article-title":"Fine needle aspiration biopsy of cystic benign lymphoepithelial lesion of the parotid gland in patients at risk for the acquired immune deficiency syndrome","volume":"34","author":"Finfer MD","year":"1990","journal-title":"Acta Cytologica"},{"key":"e_1_2_1_8_2","first-page":"361","volume-title":"Radiobiology for the radiobiologist","author":"Hall EJ","year":"1988"},{"key":"e_1_2_1_9_2","first-page":"1","volume-title":"An atlas of radiation histopathology","author":"White DC","year":"1975"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90912-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393663"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198807000-00018"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.4.250"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.5.863"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90929-P"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2643161"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880170107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880170107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:33:07Z","timestamp":1698251587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880170107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/hed.2880170107"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880170107","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}