{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:40:45Z","timestamp":1791236445058,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4157,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> Dynamic changes in cell adhesion and migration are fundamental properties of the cells that are important in hemostasis, vascularization, and wound repair. Changes in cell adhesion and migration are very important in the formation of tumors, and invasion and metastasis by neoplasms.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> Using immunolocalization and immunopurification techniques, expression of integrin molecules involved in cell adhesion has been characterized during tumor development and wound healing. The ability of cytokines to regulate expression and antibody and peptide inhibitors to inhibit function of integrins has been explored to better understand the role of integrins in pathogenesis.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Increased suprabasilar expression of the integrins \u03b16\u03b24, \u03b12\u03b21, and \u03b13\u03b21 accompanies development of squamous cell neoplasms of the head and neck. Integrin \u03b1ll\u03b23 is an integrin receptor which is important in platelet aggregation in hemostasis and formation of tumor metastases. Increased expression of integrin \u03b1v\u03b23 has been identified in angiogenesis in response to growth factors and tumor angiogenic factors. Cytokine TGF\u2010\u03b2 and arachadonic acid metabolite 12(S)\u2010HETE are important signals in regulation of integrins and affect cell aggregation and migration in these processes. Ligands and inhibitors for some of these receptors have been identified which will be useful in determining their role during tumor development and progression.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> Recent advances in understanding the functions of the integrin cell adhesion molecules may soon add new diagnostic methods and therapies to the armamentarium of the head and neck oncologic, microvascular, plastic, and reconstructive surgeon. Therapies directed at controlling integrin cell\u2010adhesion molecule expression and function are being explored to improve scar formation, bone synthesis, inhibition of vascular occlusion, and inhibition of tumor invasion and metastasis. \u00a9 1995 Jons Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/hed.2880170212","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:42:30Z","timestamp":1172097750000},"page":"140-147","source":"Crossref","is-referenced-by-count":42,"title":["Cell adhesion and regulatory molecules involved in tumor formation, hemostasis, and wound healing"],"prefix":"10.1002","volume":"17","author":[{"given":"Carter","family":"van Waes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90115-S"},{"key":"e_1_2_1_3_2","first-page":"1117","volume-title":"Otolaryngologic clinics of North America","author":"van Waes C","year":"1992"},{"key":"e_1_2_1_4_2","first-page":"3614","article-title":"Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9","volume":"46","author":"Kimmel KA","year":"1986","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.19.1566"},{"key":"e_1_2_1_6_2","first-page":"2395","article-title":"The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin \u03b16\u03b24","volume":"51","author":"van Waes C","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","first-page":"4803","article-title":"The suprabasal expression of \u03b16\u03b24 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis","volume":"53","author":"Tennenbaum T","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","first-page":"2025s","article-title":"Retinoid chemoprevention studies in upper aerodigestive tract and lung carcinogenesis","volume":"54","author":"Lippman SM","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1091\/mbc.1.3.249","article-title":"Human colon carcinoma cells use multiple receptors to adhere to laminin: involvement of \u03b16\u03b24 and \u03b12\u03b21 integrins","volume":"1","author":"Lotz MM","year":"1990","journal-title":"Cell Reg"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.3.671"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.4.1873"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910490524"},{"key":"e_1_2_1_14_2","first-page":"1574","article-title":"Endogenous 12 (s)HETE production by tumor cells and its role in metastasis","volume":"54","author":"Chen YQ","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7512751"},{"key":"e_1_2_1_16_2","unstructured":"WoodyJN. Paper presented at the Commercial Prospects of Cell Adhesion Meeting San Diego December 6 1993:."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90009-R"},{"key":"e_1_2_1_18_2","article-title":"Neutralising antibody to TGF\u2010\u03b21, 2 reduces cutaneous scarring in adult rodents","author":"Shah M","journal-title":"J Cell Science"},{"key":"e_1_2_1_19_2","unstructured":"RosenDM. Transforming growth factor\u2010\u03b2s and bone metabolism at TGF\u2010\u03b2s: biological mechanisms and clinical applications Bethesda MD May 5 1994:."}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880170212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880170212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:53:17Z","timestamp":1698288797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880170212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/hed.2880170212"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880170212","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}